Leucemie Linfomi Mielomi
Anno: 1995
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Titolo: The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytesRiferimento:J Biol Chem. 1995 Mar 31;270(13):7037-40.Azione della melatonina:Melatonin is a natural ligand of RZR alpha and RZR beta, down-regulating the expression of 5-lipoxygenase about 5-fold in B-Lymphocytes.Target:Retinoid Z receptor (RZR alpha and beta).
Anno: 1996
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Riferimento:Toxic Rep Ser. 1996 Sep;58:1-B6.Azione della melatonina:Magnetic field exposure, cause of leukemia and other cancers, was not associated with a significant reduction in serum melatonin.Target:Electric and magnetic fields.
Anno: 1997
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Titolo: Effects of melatonin on mammary gland lesions in transgenic mice overexpressing N-ras proto-oncogeneRiferimento:J Pineal Res. 1997 Mar;22(2):86-94.Azione della melatonina:Reduces the incidence of HANs and the expression of N-ras protein in focal hyperplastic lesions.Target:200 microgr/ day, five times a week, i.p.
Anno: 1998
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Riferimento:Proc Soc Exp Biol Med. 1998 Nov;219(2):144-8.Azione della melatonina:DHEA or MLT supplementation restored the average speed; ambulatory time and distance traveled of retrovirus infected mice.Target:LP-BM5 retrovirus infection.
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Titolo: Melatonin decreases bone marrow and lymphatic toxicity of adriamycin in mice bearing TLX5 lymphomaRiferimento:Life Sci. 1998;63(19):1701-13.Azione della melatonina:Protective effects of melatonin against the host toxicity of the prooxidant adriamycin.Target:A single dose,10 mg/kg s.c., 1 hour earlier.
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Riferimento:J Pineal Res. 1998 Oct;25(3):147-58.Azione della melatonina:Electron microscopy examination detected the presence of clusters of intermediate filaments and electrodense granules in the case of a germinoma producing melatonin.Target:Serum and CSF levels of melatonin.
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Riferimento:Comp Biochem Physiol A Mol Integr Physiol. 1998 Feb;119(2):493-501.Azione della melatonina:Protects bone marrow, lymphoid tissues from damaging effect of cytotoxic drugs.Target:100 μg melatonin daily intraperitoneally injected.
Anno: 1999
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Riferimento:Adv Exp Med Biol. 1999;460:407-9.Azione della melatonina:(No abstract available).Target:(No abstract available).
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Riferimento:Immunology. 1999 Feb;96(2):291-7.Azione della melatonina:Dhea and Mlt simultaneously reduced hepatic lipid peroxidation and prevent vitamin E loss.Target:Prevent (Th1, Th2) cyto-kine dysregulation.
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Riferimento:BMJ. 1999 Jan 23;318(7178):224-8.Azione della melatonina:Di Bella multitherapy did not show sufficient efficacy in patients with advanced cancer to warrant further clinical testing.Target:386 patients with advanced cancer were enrolled.