Melatonina
Anno: 2002
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Riferimento:Environ Health Perspect. 2002 Feb;110(2):A72-3.Azione della melatonina:No abstract availableTarget:No abstract available
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Riferimento:Med Hypotheses. 2002 Jul;59(1):39-51.Azione della melatonina:Elevated magnetic field exposures associated with breast and other cancers has been postulated via modified melatonin activity.Target:ELF
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Riferimento:Am J Epidemiol. 2002 Mar 1;155(5):446-54.Azione della melatonina:These data do not support the hypothesis that exposure to residential magnetic fields (60-Hz) is associated with an increased risk of breast cancer.Target:ELF
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Riferimento:Pol J Pathol. 2002;53(2):59-65.Azione della melatonina:Retinoids induce the apoptotic pathway in a dose-dependent manner, melatonin (10(-5) M) added to the culture enhances this effect.Target:Estrogen sensitive (ER+)
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Riferimento:Breast Cancer Res Treat. 2002 Jan;71(1):37-45.Azione della melatonina:Melatonin pre-treatment ((10(-9)-10(-6) M) for 30 min) significantly reduced E2-induced ERalpha transactivation and Eralpha-ERE(estrogen response element) binding activity.Target:Estrogen receptor-alpha (ERalpha)
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Riferimento:Mol Cell Endocrinol. 2002 Jun 28;192(1-2):147-56.Azione della melatonina:Involvement of the MT(1) melatonin receptor in mediation of melatonin effects on growth-suppression and gene-modulation in breast cancer cells.Target:MT(1) receptor
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Riferimento:Epidemiology. 2002 Jan;13(1):116.Azione della melatonina:No abstract available.Target:No abstract available.
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Riferimento:J Pineal Res. 2002 Mar;32(2):90-6.Azione della melatonina:Melatonin (1nM) and dihydroxycholecalciferol (D3) (100 nM) reduce MCF-7 cell proliferation by modulating cell-cycle length through the control of the p53-p21 pathway.Target:D3/p53/p21
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Titolo: Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cellsRiferimento:J Pineal Res. 2002 Mar;32(2):112-9.Azione della melatonina:Melatonin (10(-7) M) effects on the Ca2+/CaM path-way play a role in the growth-inhibitory on MCF-7 human breast cancer cells.Target:(Ca2+)/calmodulin (CaM)
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Riferimento:Med Sci Monit. 2002 Jun;8(6):CR457-61.Azione della melatonina:A negative correlation between plasma melatonin and IGF-I concentrations in patients with neoplastic disease imply an additional defense mechanism based on the oncostatic influence of melatonin.Target:Insulin-like growth factor-I (IGF-I)