Melatonina
Anno: 2004
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Riferimento:Psychoneuroendocrinology. 2004 May;29(4):448-74.Azione della melatonina:MBSR program enrollment was associated with enhanced quality of life and decreased stress symptoms in breast and prostate cancer patients, and resulted in possibly beneficial changes in HPA axis functioning.Target:Mindfulness-Based Stress Reduction (MBSR) - Hypothalamic-pituitary--adrenal (HPA)
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Riferimento:Environ Sci. 2004;11(3):163-70.Azione della melatonina:Melatonin (10(-10) M) caused a transient inhibition of cell growth of estrogen receptor alpha-positive MCF-7-EMF cells induced synergistically by both insulin-like growth factor-1 and bisphenol A.Target:Eralpha, IGF-1.
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Riferimento:Cancer Lett. 2004 Dec 8;216(1):73-80.Azione della melatonina:These results support a cross-talk between membran and nuclear melatonin signalling and provide new data on the hormonal regulation of telomerase function (telomerase reverse transcriptase/TERT, telo-merase RNA/TR).Target:TERT/TR.
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Riferimento:J Pineal Res. 2004 Oct;37(3):213-4.Azione della melatonina:No abstract available.Target:No abstract available.
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Riferimento:Med Hypotheses. 2004;63(4):588-96.Azione della melatonina:Constant light suppressed MLT, increased cancer cell growth rates, and increased linoleic acid (LA) uptake into cancer cells.Target:LAN
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Titolo: Light at night and cancer riskRiferimento:Photochem Photobiol. 2004 Apr;79(4):316-8.Azione della melatonina:Studies for an association between Mlt suppression, night work as a surrogate, and breast cancer risk.Target:LAN.
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Riferimento:J Biol Chem. 2004 Sep 10;279(37):38294-302.Azione della melatonina:Melatonin acts as a calmodulin antagonist inducing conformational changes in the Eralpha-calmodulin (CaM) complex, thus impairing the binding of E(2).Target:Estrogen receptor (ER).
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Titolo: Epidemiology of urinary melatonin in women and its relation to other hormones and night workRiferimento:Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):936-43.Azione della melatonina:Night shifts workers seem to experience changes in hormone levels (6-sulfatoxymelatonin) that may be associated with the increased cancer risk observed.Target:6-sulfatoxymelatonin
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Riferimento:J Natl Cancer Inst. 2004 Jun 2;96(11):888-9.Azione della melatonina:Independent information about nocturnal light exposure of each case patient and control subject is essential for assessing melatonin-modulated cancer risk.Target:LAN
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Riferimento:Biochem Pharmacol. 2004 Nov 1;68(9):1869-78.Azione della melatonina:6-Hydroxymelatonin induced site-specific DNA damage in the presence of Cu(II). Damaged G and C of the 5'-ACG-3' sequence complementary to codon 273 of the p53 gene.Target:Oxidative DNA damage by its metabolite.