Melatonina
Anno: 2004
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Titolo: Epidemiology of urinary melatonin in women and its relation to other hormones and night workRiferimento:Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):936-43.Azione della melatonina:Night shifts workers seem to experience changes in hormone levels (6-sulfatoxymelatonin) that may be associated with the increased cancer risk observed.Target:6-sulfatoxymelatonin
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Riferimento:Biochem Pharmacol. 2004 Nov 1;68(9):1869-78.Azione della melatonina:6-Hydroxymelatonin induced site-specific DNA damage in the presence of Cu(II). Damaged G and C of the 5'-ACG-3' sequence complementary to codon 273 of the p53 gene.Target:Oxidative DNA damage by its metabolite.
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Riferimento:J Natl Cancer Inst. 2004 Jun 2;96(11):888-9.Azione della melatonina:Independent information about nocturnal light exposure of each case patient and control subject is essential for assessing melatonin-modulated cancer risk.Target:LAN
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Riferimento:J Cell Biochem. 2004 Sep 1;93(1):83-92.Azione della melatonina:Electromagnetic field (EMF) and extremely low frequency (ELF) exposure is able to perform such activation by means of increasing levels of free radicals, causing an inhibition of the effects of the melatonin.Target:DNA damage.
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Titolo: Light at night and cancer riskRiferimento:Photochem Photobiol. 2004 Apr;79(4):316-8.Azione della melatonina:Studies for an association between Mlt suppression, night work as a surrogate, and breast cancer risk.Target:LAN.
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Riferimento:Psychoneuroendocrinology. 2004 May;29(4):448-74.Azione della melatonina:MBSR program enrollment was associated with enhanced quality of life and decreased stress symptoms in breast and prostate cancer patients, and resulted in possibly beneficial changes in HPA axis functioning.Target:Mindfulness-Based Stress Reduction (MBSR) - Hypothalamic-pituitary-adrenal (HPA)
Anno: 2005
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1333-5.Azione della melatonina:Significant positive association between vegetable intake and urinary aMT6-s levels. This association may be explained by the melatonin contained in vegetables.Target:6-sulfatoxymelatonin (aMT6-s)
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Riferimento:Breast Cancer Res Treat. 2005 Dec;94(3):249-54.Azione della melatonina:Treatment with melatonin (1 nM) followed by aminoglutethimide is the most effective way of reducing the aromatase activity in the MCF-7 cell line.Target:Aromatase mRNA.
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Riferimento:J Pineal Res. 2005 May;38(4):231-9.Azione della melatonina:This demonstrates that GPCRs can modulate the transcriptional activity of various steroid receptors (Eralpha, GR, RARalpha) in response to their ligand through activation of different G protein signaling pathways.Target:MT1 G protein-coupled, estrogen receptor alpha, glucocorticoid, retinoic acid receptor alpha.
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Riferimento:Anticancer Res. 2005 Nov-Dec;25(6B):4245-8.Azione della melatonina:Importance of time sequence for melatonin administration (during or 1 hour after) to exert its protective effect to doxorubicin treatment, independent from its antioxidant function.Target:Antioxidant function.