Melatonina
Anno: 2007
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Riferimento:Oncol Rep. 2007 Apr;17(4):947-53.Azione della melatonina:Melatonin inhibits both aromatase activity as a selective estrogen enzyme modulator. 20% at 1 nM; 40% at 10 microM Mlt concentrations.Target:MT1 melatonin receptor.
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Riferimento:Eur J Pharmacol. 2007 Mar 29;560(1):17-22.Azione della melatonina:A combination of valproic acid (0.5, 1.0 or 5 mM) and melatonin (1 or 10 nM) suggests that a similar approach may be beneficial in breast cancer.Target:MT1 Mlt receptor mRNA.
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Riferimento:Chem Res Toxicol. 2007 Dec;20(12):1947-53.Azione della melatonina:N-acetylcysteine, melatonin, reduced lipoic acid and resveratrol can inhibit the formation of depurina- ting estrogen-DNA adducts.Target:Estradiol (E2)-3,4-quinone (Q).
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Riferimento:J Behav Med. 2007 Feb;30(1):45-58.Azione della melatonina:Forty percent of the women with breast cancer had stage 2 disease and they were an average of 1.36years post-diagnosis. Women with breast cancer had significantly higher levels of disturbance on all the psychological indices.Target:Dysregulations across systems in breast cancer patients.
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2509-12.Azione della melatonina:In premenopausal women, the urinary aMT6-s level was significantly positively associated with percent mammographic density. No evidence that the melatonin level is inversely associated with mammographic density.Target:(aMT6-s). 6-sulfatoxymelatonin
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Riferimento:Epidemiology. 2007 Mar;18(2):266-9.Azione della melatonina:Exposure to 60-Hz magnetic fields may increase breast cancer risk by suppressing the nocturnal production of melatonin.Breast cancer risk was not associated with exposure to residential magnetic fields, regardless of medication use.Target:Magnetic fields.
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Riferimento:Scand J Work Environ Health. 2007 Oct;33(5):336-43.Azione della melatonina:No evidence was found for an association between shift work and breast or prostate cancer, or all cancer sites combined among shift workers.Target:Nighttime shift workers.
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Titolo: Inhibition of proliferation and induction of apoptosis by melatonin in human myeloid HL-60 cellsRiferimento:J Pineal Res. 2007 Mar;42(2):131-8.Azione della melatonina:Inhibiting progression from G(1) to S phase of the cell cycle and increasing apoptotic cell death.Target:Elevated cytochrome c release from mitochondria augmented caspase-3 and caspase-9 activities, regulation of Bax/Bcl-2 expression.
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Riferimento:Prof Inferm. 2007 Apr-Jun;60(2):89-93.Azione della melatonina:Nurses who attend night shifts should undergo strict and periodical breast cancer screening, since the risk is significantly increased in this population.Target:Light-at-night
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Riferimento:Mol Cell Biochem. 2007 Jan;294(1-2):19-24.Azione della melatonina:Intense exercise-induced stress enhances mammary carcinogenesis through the involvement of adrenaline and prolactin, also confirmed a role of melatonin as a therapeutic aid against breast cancer in general.Target:"Anti-stress" role of Mlt.