Melatonina
Anno: 2008
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Riferimento:J Pineal Res. 2008 Nov;45(4):476-88.Azione della melatonina:The growth-inhibitory actions of melatonin are mediated via both G(alphai2) and G(alphaq) proteins.Target:MT1 G protein-coupled receptor.
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Riferimento:Biochem Pharmacol. 2008 Feb 1;75(3):713-24.Azione della melatonina:Indole-3-carbinol (I3C)induces a G1 cell cycle arrest of human breast cancer cells,whereas both tryptophol and melatonin failed to induce the cell cycle arrest.Target:Indole-3-carbinol (I3C)
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Riferimento:Neuro Endocrinol Lett. 2008 Dec;29(6):857-66.Azione della melatonina:Use of MDB as the first line therapy, in a patient which had not been debilitated by the effects of chemo-and radiotherapy, contributed greatly to the final outcome.Target:(MDB)
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Riferimento:Toxicol Lett. 2008 Oct 1;181(3):190-5.Azione della melatonina:Melatonin increases Cd-induced expression of MT-2A, which is considered to protect against Cd toxicity, modulating MTs synthesis.Target:Cadmium (Cd) Metallothioneins (MTs)
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Riferimento:Med Hypotheses. 2008 Dec;71(6):862-7.Azione della melatonina:Portion of the survival benefit of Aromatase inhibtors (AIs) is due to their indirect effect on melatonin, not just their direct effect on estrogen.Target:Aromatase inhibitors (AIs)
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Riferimento:J Pineal Res. 2008 Nov;45(4):341-50.Azione della melatonina:Highly protective of oxidative damage to the human hemopoietic system.Target:Disruption of nocturnal melatonin synthesis andrelated circadian rhythms by electric fields.
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Riferimento:Curr Cancer Drug Targets. 2008 Dec;8(8):691-702.Azione della melatonina:Melatonin inhibits the growth of breast cancer by interacting with estrogen-signaling(SERM)-(SEEM) pathways.Target:Selective estrogen recetor modulator (SERM), selective estrogen enzyme modulator (SEEM).
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Riferimento:Eur J Cancer Prev. 2008 Oct;17(5):467-72.Azione della melatonina:Positive relationship between the sleep variation and E2 levels (60% lower) in women of reproductive age.Target:17-beta estradiol (E2)
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Titolo: An indomethacin analogue...Riferimento:Biochem Pharmacol. 2008 Jan 15;75(2):484-93.Azione della melatonina:Identification of CBM as a specific inhibitor of AKR1C3 and the resultant effects on prostate and breast cancer cells.Target:N-(4-chlorobenzoyl)- melatonin (CBM)
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Titolo: Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary walnutRiferimento:Nutr Cancer. 2008;60(5):666-74.Azione della melatonina:Tumor cell proliferation was decreased, but apoptosis was not altered due to walnut consumption.Target:Walnuts diet.