Melatonina
Anno: 2009
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Riferimento:Med Hypotheses. 2009 Sep;73(3):324-5.Azione della melatonina:Wearing amber glasses(or using blue-free light bulbs) for a few hours before bedtime maximizes melatonin production and reduces the risk of breast, ovarian and prostate cancer.Target:Blue wavelengths=loss of melatonin.
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Riferimento:Pathophysiology. 2009 Aug;16(2-3):149-56.Azione della melatonina:Exposure to ELF/MF increase the risk of both Alzheimer's disease and breast cancer, increasing production of amyloid beta/decreasing production of Mlt.Target:Extremely low frequency (ELF), magnetic fields (Mfs).
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Riferimento:Integr Cancer Ther. 2009 Dec;8(4):337-46.Azione della melatonina:MT1 receptor is a major transducer of melatonin's actions in the breast, suppressing mammary gland development and mediating the anticancer actions of melatonin.Target:Clock gene BMAL1 and Period 2 (Per2).
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Titolo: Defining chronodisruptionRiferimento:J Pineal Res. 2009 Apr;46(3):245-7.Azione della melatonina:Melatonin being a key biological intermediary, via circadian disruption with epidemic cancers such as of the breast or prostate.Target:Chronodisruption (CD)
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Riferimento:Expert Rev Mol Med. 2009 Feb 5;11:e5.Azione della melatonina:Potential use of melatonin in breast cancer prevention and treatment.Target:Oestrogen-dependent, free-radical formation.
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Riferimento:Breast Cancer Res Treat. 2009 May;115(1):13-27.Azione della melatonina:The oncostatic properties of melatonin as they involve epigenetic mechanisms of cancer are reviewed.Target:Eralpha, aromatase, CYP19 histones,cyclin D1 LAN, PER2.
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Riferimento:J Pineal Res. 2009 Sep;47(2):147-55.Azione della melatonina:Enhances radiation-induced apoptosis in Jurkat leukemia cells, while reducing radiation-induced apoptosis in normal mice splenocytes.Target:Increase of Bcl-2 expression and a reduction of Bax/Bcl-2 ratio through a relative decrease of p53 mRNA and protein.
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Riferimento:Integr Cancer Ther. 2009 Dec;8(4):354-60.Azione della melatonina:The three major consequences of light at night are sleep deprivation, chronodisruption, and melatonin suppression.Target:LAN
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Riferimento:J Pineal Res. 2009 Mar;46(2):172-80.Azione della melatonina:Two distinct apoptotic processes are triggered by melatonin(1 nM), an early, TGFbeta1 and caspase-independent response, and a late TGFbeta1-dependent process in which activated-caspase-7.Target:Transforming growth factor beta 1 (TGFbeta1)
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Riferimento:J Pineal Res. 2009 May;46(4):392-400.Azione della melatonina:Has proapoptotic and/or oncostatic effects in the human myeloid cell line HL-60.Target:Treatment (1 mM) induced a significant increase in caspase-3 and -9 activities.