Melatonina
Anno: 2011
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Riferimento:Biochem Biophys Res Commun. 2011 Feb 25;405(4):593-8.Azione della melatonina:MLT showed a great potential to control the preneo-plastic patterns induced by constant light (LL).Target:MLT-supplementation (10mg/kg/day).
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Riferimento:Oncogene advance online publication, 17 October 2011Azione della melatonina:Reduce the risks of developing cancer and preventing DNA damage.Target:Phosphorylation of p53 at Ser-15
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Riferimento:Breast Cancer Res Treat. 2011 May;127(1):91-8.Azione della melatonina:Abstract Mammary tumor growth is associated with old age and diminished levels of MLT and MT1 receptor during old age, resulting in reduced sensitivity to exogenous MLT.Target:MLT and its MT1 receptor.
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Riferimento:In Vivo. 2011 May-Jun;25(3):405-9.Azione della melatonina:Does not interfere with the cytotoxic effect of cytara-bine, daunorubicin and etoposide in leukemia cells.Target:10(-5) M and 10(-3) M concentrations of MLT.
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Riferimento:EPMA J. 2011 Dec;2(4):351-6.Azione della melatonina:Shift workers suffer from a disruption of the sleep-wake rhythm, insomnia and a lack of melatonin. These factors might trigger the development of breast cancer in female shift workers.Target:Shift work
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Titolo: Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cellsRiferimento:Mol Cell Biochem. 2011 Jul;353(1-2):167-76.Azione della melatonina:Increased the apoptotic effects of H(2)O(2) in human myeloid HL-60 cells.Target:ROS production inducing tumour cell death.
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Riferimento:J Pineal Res. 2011 Apr;50(3):345-55.Azione della melatonina:Induction of cell death in several human malignant haematological cell lines through the activation of the extrinsic pathway of apoptosis.Target:Death receptors Fas, DR4 and DR5 and their ligands Fas L and TRAIL.
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Riferimento:J Pineal Res. 2011 May;50(4):367-73.Azione della melatonina:Significantly augmented the cytotoxicity of puro-mycin in HL-60 cells.Target:AMPK.phosphorylation of 5'-
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Titolo: Melatonin and associated signaling pathways that control normal breast epithelium and breast cancerRiferimento:J Mammary Gland Biol Neoplasia. 2011 Sep;16(3):235-45.Azione della melatonina:Light-at-night (LAN) induced circadian disruption of the nocturnal melatonin signal activates human breast cancer growth.Target:MT(1)melatonin receptors Estrogen receptor-positive (Erα+), G(αi2) signaling.
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Riferimento:J Pineal Res. 2011 Oct;51(3):345-52.Azione della melatonina:MLT may modulate miRNA and gene expression as an anticancer mechanism in MCF-7 human breast cancer cells.Target:MicroRNAs (miRNAs).