Melatonina
Anno: 2011
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Titolo: Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cellsRiferimento:Mol Cell Biochem. 2011 Jul;353(1-2):167-76.Azione della melatonina:Increased the apoptotic effects of H(2)O(2) in human myeloid HL-60 cells.Target:ROS production inducing tumour cell death.
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Riferimento:J Pineal Res. 2011 Apr;50(3):345-55.Azione della melatonina:Induction of cell death in several human malignant haematological cell lines through the activation of the extrinsic pathway of apoptosis.Target:Death receptors Fas, DR4 and DR5 and their ligands Fas L and TRAIL.
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Riferimento:J Pineal Res. 2011 May;50(4):367-73.Azione della melatonina:Significantly augmented the cytotoxicity of puro-mycin in HL-60 cells.Target:AMPK.phosphorylation of 5'-
Anno: 2012
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Riferimento:Am J Epidemiol. 2012 Nov 1;176(9):760-3.Azione della melatonina:Direct oncostatic properties of melatonin in shift-work-cancer association.Target:Night-shift work
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Riferimento:Eur J Cancer Prev. 2012 Mar;21(2):163-70.Azione della melatonina:Resveratrol in combination with melatonin has some protective effects on N-methyl-N-nitrosourea (NMU)-induced rodent breast cancer.Target:Chemoprevention with resveratrol and mlt.
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Riferimento:J Pineal Res. 2012 Aug 16.Azione della melatonina:Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.Target:Vascular endothelial growth factor (VEGF)
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Riferimento:Cell Mol Life Sci. 2012 Sep 25.Azione della melatonina:Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.Target:Melatonin acts at different physiological levels.
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Riferimento:Breast Cancer (Auckl). 2012;6:137-50.Azione della melatonina:Melatonin administration following serum shock differentially suppressed or induced clock gene (Bmal1 and Per2) and CCG expression in MCF10A and MCF-7 cells.Target:Clock and clock-controlled genes (CCGs)
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Riferimento:J Pineal Res. 2012 Jan;52(1):12-20.Azione della melatonina:Mlt (1mM) could stimulate the differentiation of preadipocytes (3T3-L1) into adipocytes.Target:3T3-L1 adipocytes.
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Riferimento:Mol Endocrinol. 2012 Nov;26(11):1808-20.Azione della melatonina:Melatonin activates GSK3β by inhibiting epithelial-to-mesenchymal transition, a fundamental process underlying cancer metastasis.Target:Glycogen synthase kinase 3β (GSK3β)