Neoplasie della mammella

Target

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Azione della melatonina

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Anno: 1985

Titolo: Melatonin and malignant disease

Riferimento:
Ciba Found Symp. 1985;117:284-99.

Azione della melatonina:
Melatonin may protect against tumours through an effect on prolactin secretion/on oestrogen receptors.

Target:
Mlt/oestrogen receptors

Anno: 1986

Titolo: Melatonin circadian-stage-dependently delays breast tumor development in mice injected daily for several months

Riferimento:
Chronobiologia. 1986 Apr-Jun;13(2):123-8

Azione della melatonina:
Administration time of melatonin is an indispensable complement to dosing, notably when effects upon tumorigenesis are involved.

Target:
Mlt daily injections
Titolo: Effects of melatonin on cancer: studies on MCF-7 human breast cancer cells in culture

Riferimento:
J Neural Transm Suppl. 1986;21:433-49.

Azione della melatonina:
Physiological concentrations of mlt has inhibitory effects on MCF-7 cancer cell growth in culture.

Target:
Mlt/estradiol/ prolactin

Anno: 1987

Titolo: The clinical significance of melatonin serum determination in oncological patients and its correlations with GH and PRL blood levels

Riferimento:
Eur J Cancer Clin Oncol. 1987 Jul;23(7):949-57.

Azione della melatonina:
The oncological patients showed higher mean melatonin serum levels than the control subjects. Mlt values were lower in patients with solid tumours who had metastases. Chemotherapy caused a decre- ase. Surgery was followed by a fall in melatonin in patients without metastases.

Target:
Mlt/oncological patients
Titolo: Correlation between changes in prolactin and melatonin serum levels after radical mastectomy

Riferimento:
Tumori. 1987 Jun 30;73(3):263-7.

Azione della melatonina:
MLT serum values were significantly higher in patients than in controls. Radical mastectomy influences PRL and MLT secretions.

Target:
Prolactin (PRL) Melatonin (MLT)
Titolo: Melatonin: perspectives in laboratory medicine and clinical research

Riferimento:
Crit Rev Clin Lab Sci. 1987;25(3):231-53. Review.

Azione della melatonina:
Great decline in the elevated melatonin level of oncological patients following institution of chemotherapy.

Target:
Mlt induce mitotic arrest

Anno: 1988

Titolo: Melatonin increase as predictor for tumor objective response to chemotherapy in advanced cancer patients

Riferimento:
Tumori. 1988 Jun 30;74(3):339-45.

Azione della melatonina:
Patients (75%) whose mlt enhanced after chemotherapy had an objective regression.

Target:
Mlt as a predictor
Titolo: Inhibition of Dunning tumor growth by melatonin

Riferimento:
J Urol. 1988 May;139(5):1099-102.

Azione della melatonina:
MCF breast cancer tissue indicate an estrogen requirement for inhibition of growth by melatonin.

Target:
Inhibit tumor growth
Titolo: Neuroimmunomodulation in cancer patients: correlations between melatonin and beta-endorphin blood levels and T helper/suppressor ratio

Riferimento:
Int J Biol Markers. 1988 Apr-Jun;3(2):82-6.

Azione della melatonina:
Metastatic patients had lower melatonin levels and a lower T4/T8 ratio.

Target:
MLT/ beta-endorphin
Titolo: Di-iodothyronine as part of the oestradiol and catechol oestrogen receptor--the role of iodine, thyroid hormones and melatonin in the aetiology of breast cancer

Riferimento:
Med Hypotheses. 1988 Dec;27(4):303-11.

Azione della melatonina:
Hypothalamic-pituitary axis could be significant in the aetiology of breast cancer as high prolactin and melatonin levels may be protective.

Target:
Hypothyroidism

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