Neoplasie della mammella
Anno: 1997
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Riferimento:Support Care Cancer. 1997 Mar;5(2):126-9.Azione della melatonina:Concomitant administration of MLT during chemo-therapy may prevent some chemotherapy-induced side-effects,Target:Influence of MLT on chemotherapy toxicity.
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Riferimento:Bioelectromagnetics. 1997;18(8):555-62.Azione della melatonina:Melatonin (10(-9) M) and tamoxifen (10(-7) M) may act through different biological pathways to down-regulate cell growth.Target:EMF (1.2 microT, 60 Hz).
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Riferimento:Breast Cancer Res Treat. 1997 Jan;42(1):15-22.Azione della melatonina:Breast cancer women had a reversal of the normal seasonal pattern of melatonin secretion.Target:Seasonal variation.
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Riferimento:Cancer Lett. 1997 Jan 1;111(1-2):59-66.Azione della melatonina:Combined therapy of melatonin (200 microg/day, p.o.) and tamoxifen is highly promising in the prophylaxis of breast carcinogenesis in humans.Target:Melatonin/tamoxifen
Anno: 1998
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Riferimento:Int J Biol Markers. 1998 Jul-Sep;13(3):154-7.Azione della melatonina:Studies evaluating circadian DHEAS secretion in relation in that of the pineal hormone MLT.Target:Dehydroepiandrosteronesulfate (DHEAS).
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Riferimento:Br J Cancer. 1998 Jun;77(12):2129-37.Azione della melatonina:Melatonin (10(-9) M)and atRA (10(-9) M) should be considered for preclinical and clinical evaluation against ER-positive human breast cancer.Target:Oestrogen receptor (ER), all-trans retinoic acid (atRA).
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Riferimento:Mol Carcinog. 1998 Mar;21(3):149-55. Review.Azione della melatonina:Reduction of melatonin levels by EMFs can caused inactivation of melatonin receptors which may cause cancer.Target:Electromagnetic fields (EMFs).
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Riferimento:J Membr Biol. 1998 Mar 1;162(1):59-65.Azione della melatonina:Synergistic effects of tamoxifen (50-200 microM) and melatonin (1 mM) in stabilizing biological membranes may be important in protecting membranes from free radical damage.Target:Tamoxifene/Melatonin.
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Riferimento:J Pineal Res. 1998 Dec;25(4):211-8.Azione della melatonina:Melatonin has no inhibitory effects on human breast cancer cells at (1x10(-11) to 1x10(-9) M) concentrations.Target:Estrogen-receptorEstrogen-receptor.
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Riferimento:Cancer Lett. 1998 Jan 9;122(1-2):17-23.Azione della melatonina:The direct antiproliferative effect of melatonin thus seems to be confined to a melatonin-responsive subclone of MCF-7 cells and not applicable to the majority of cancer cells.Target:MCF-7 human breast cancer cells.