Riferimento:
Biol Signals Recept. 1999 Jan-Apr;8(1-2):75-8.
Autori:
Karasek M, Pawlikowski M.
Fonte:
Biol Signals Recept. 1999 Jan-Apr;8(1-2):75-8.
Anno:
1999
Azione:
Melatonin may influence the proliferation of tumor cells via RZR/ROR receptors.
Target:
CGP 52608 ligand for RZR/ROR receptors.
Abstract
The antiproliferative effects of melatonin and CGP 52608, an exogenous ligand for RZR/ROR receptors, are compared in the present paper. Both compounds exerted similar inhibitory effects on the proliferation of neoplastic cells in mouse colonic adenocarcinoma, DU 145 human prostatecancer, MCF-7 human breast carcinoma, and rat diethylstilbestrol-induced prolactinoma. Although it has been suggested that melatonin may influence the proliferation of tumor cells via RZR/ROR receptors, it cannot be excluded that the antiproliferative effects of melatonin and CGP 52608 are unrelated and mediated by different intracellular mechanisms.
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