Circulating tumoral cells lack circadian-rhythm in hospitalized metastasic breast cancer patients

Riferimento:

Clin Transl Oncol. 2006 Nov;8(11):826-9.

Autori:

García-Sáenz JA, Martín M, Maestro M, Vidaurreta M, Veganzones S, Villalobos L, Rodríguez-Lajusticia L, Rafael S, Sanz-Casla MT, Casado A, Sastre J, Arroyo M, Díaz-Rubio E.

Fonte:

Servicio de Oncología Médica. Hospital Universitario San Carlos. Madrid. Spain. jagsaenz@yahoo.com

Anno:

2006

Azione:

Increased breast tumorigenesis has been reported in melatonin-suppressed experimental models.

Target:

Circulating Tumor Cells (CTC) circadian- rhythm.

Abstract. Background: The relationship between breast cancer and circadian rhythm variation has been extensively studied.

Abstract

BACKGROUND:

The relationship between breast cancer and circadian rhythm variation has been extensively studied. Increased breast tumorigenesis has been reported in melatonin-suppressed experimental models and in observational studies.

OBJECTIVES:

Circulating Tumor Cells (CTC) circadian- rhythm may optimize the timing of therapies. This is a prospective experimental study to ascertain the day-time and night-time CTC levels in hospitalized metastasic breast cancer (MBC) patients.

MATERIAL AND METHODS:

CTC are isolated and enumerated from a 08:00 AM and 08:00 PM blood collections. 23 MBC and 23 healthy volunteers entered the study. 69 samples were collected (23 samples at 08:00 AM and 23 samples at 08:00 PM from MBC; 23 samples from healthy volunteers). Results from two patients were rejected due to sample processing errors. No CTC were isolated from healthy-volunteers.

RESULTS AND DISCUSSION:

No-differences between daytime and night-time CTC were observed. Therefore, we could not ascertain CTC circadian-rhythm in hospitalized metastasic breast cancer patients.

Patologie:

Neoplasie della mammella

Sostanze:

Melatonina