ABSTRACT
Research has indicated that excessive vitamin A can have deleterious impacts on bone. Retinoic acid (RA), the most active metabolite of vitamin A, has been tested in clinical trials for treatment of lung cancer and emphysema. These trials are not measuring Bone Mineral Content (BMC) or Bone Mineral Density (BMD). In this study, we used an animal model to determine potential deleterious effects of all-trans RA on bone mass when used as a means to protect against or treat cigarette smoke-induced lung injuries, and also to evaluate BMC as a potential early indicator of osteoporosis risk. Twenty-four male weanling rats were fed either a control diet or a RA-supplemented diet. Half of each group was exposed to 40 cigarettes per day, 5 days per week, for 4 weeks. BMC and BMD were measured at weeks 2 and 4. RA supplementation in all groups significantly decreased (p < 0.05) only BMC at week 2 and both BMC and BMD (both p < 0.05) at week 4. The same results were observed when BMC was expressed relative to body weight. These data suggest that caution should be used when RA is used to treat smoke-related lung injuries.
Decreases in bone mineral content by dietary all-trans retinoic acid precede decreases in bone mineral density in a weanling rat model of cigarette smoke-induced lung injuries
Riferimento:
Int J Vitam Nutr Res. 2011 Jan;81(1):5-11.
Autori:
Xue Y, Haub MD, Smith BW, Baybutt RC.
Fonte:
Int J Vitam Nutr Res. 2011 Jan;81(1):5-11.
Anno:
2011
Azione:
L'acido retinoico (RA), il metabolita più attivo della vitamina A, è stato testato in studi clinici per il trattamento del cancro polmonare e dell'enfisema. Queste prove non misurano il contenuto minerale osseo (BMC) o la densità minerale ossea (BMD). La ricerca ha indicato che un uso eccessivo di vitamina A può avere effetti deleteri su entrambi questi fattori.
Target:
RA/cancro polmonare ed enfisema.
Sostanze: