Riferimento:
Intern Med. 2011;50(24):3037-41.
Autori:
Machida H, Shinohara T, Iwahara Y, Hatakeyama N, Okano Y, Nakano M, Hosokawa E, Abe S, Naruse K, Ogushi F. machidah@Kochi2.hosp.go.jp
Fonte:
Intern Med. 2011;50(24):3037-41.
Anno:
2011
Azione:
La remissione parziale è stata ottenuta dopo il trattamento con acido all-trans retinoico (ATRA), seguita da chemioterapia, in un paziente con leucemia mieloide acuta con i cambiamenti correlati alla mielodisplasia.
Target:
ATRA/leucemia mieloide acuta.
ABSTRACT
We describe a patient with acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) that clinically resembled acute promyelocytic leukemia (APL). The karyotype of his leukemic cells was 46, XY, del (3) (q?) and did not include a chromosomal translocation involving the retinoic acid receptor-α gene. However, retinoic acid syndrome developed, and partial remission was achieved after treatment with all-trans retinoic acid (ATRA) followed by chemotherapy. Our case might provide new insights into the mechanism of the growth inhibitory effect of ATRA on APL-like cells.
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