Leucemie Linfomi Mielomi

Leucemie Linfomi Mielomi

Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation

J Pineal Res. 2005 Nov;39(4):425-31.
Trubiani O, Recchioni R, Moroni F, Pizzicannella J, Caputi S, Di Primio R.
Apoptotic effect of melatonin is associated with cell-cycle arrest, downregulation of Bcl-2, mitochondrial membrane depolarization, cytochrome c release and activation of caspase-3.
Bcl-2, Cytochrome c, Caspase-3.

Relapse of high-grade non-Hodgkin's lymphoma after autologous stem cell transplantation: a case successfully treated with cyclophosphamide plus somatostatin, bromocriptine, melatonin, retinoids, and ACTH

Am J Ther. 2006 Nov-Dec;13(6):556-7.
Todisco M.
After 2 months, patient had a partial response, and after 5 months he achieved a complete response.
High-grade NHL after auto-SCT.

Low-grade non-Hodgkin lymphoma at advanced stage: a case successfully treated with cyclophosphamide plus somatostatin, bromocriptine, retinoids, and melatonin

Am J Ther. 2007 Jan-Feb;14(1):113-5.
Todisco M.
After 2 months the patient had a partial response, and after 5 months he achieved a complete response.
Treatment had very good tolerance.

Effects of exogenous melatonin and circadian synchronization on tumor progression in melanoma-bearing C57BL6 mice

J Pineal Res. 2008 Apr;44(3):307-15.
Otálora BB, Madrid JA, Alvarez N, Vicente V, Rol MA.
Melatonin administration (2 mg/kg BW/day) enhances survival under LD conditions, the results are self-defeating when they coexist with circadian disruption as under LL conditions.
Light-dark (LD) Continuous light (LL).

The effects of melatonin on glutathione peroxidase activity in serum and erythrocytes after adriamycin in normal and pinealectomised rats

Endokrynol Pol. 2008 May-Jun;59(3):200-6.
Dbrowska K, Stuss M, Gromadzińska J, Wasowicz W, Sewerynek E.
Not influenced the activity of GSH-Px, either in normal or in pinealectomised rats after ADR. A deficiency of endogenous melatonin production may inhibit GSH-Px activity.
ADR; GSH-Px.

Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis

J Pineal Res. 2012 Apr;52(3):322-31.
Zha L, Fan L, Sun G, Wang H, Ma T, Zhong F, Wei W.
Melatonin sensitizes human hepatoma cells to ER tress-induced apoptosis by down-regulating COX-2 xpression, incresing the levels of CHOP and decreaing the Bcl-2/Bax ratio.
Endoplasmin reticulum, Cyclooxygenase-2, Pro-apoptotic transcription factor.

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