Melatonina

Selective estrogen enzyme modulator actions of melatonin in human breast cancer cells

J Pineal Res. 2008 Aug;45(1):86-92.
Gonzalez A, Cos S, Martinez-Campa C, Alonso-Gonzalez C, Sanchez-Mateos S, Mediavilla MD, Sanchez-Barcelo EJ.
Melatonin, at physiologic concentrations, modulates the inhibition of sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) activity.
Sulfatase (STS) 17beta-HSD1

Effects of exogenous melatonin and circadian synchronization on tumor progression in melanoma-bearing C57BL6 mice

J Pineal Res. 2008 Apr;44(3):307-15.
Otálora BB, Madrid JA, Alvarez N, Vicente V, Rol MA.
Melatonin administration (2 mg/kg BW/day) increased the BT rhythm amplitude and phase stability, reduced tumor weight and prevented intraperitoneal dissemination.
Body Temperature (BT)

Melatonin down-regulates hTERT expression induced by either natural estrogens (17beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells.

Carcinogenesis. 2008 Jun;29(6):1244-8.
Martínez-Campa CM, Alonso-González C, Mediavilla MD, Cos S, González A, Sanchez-Barcelo EJ.
Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors.
HumanTelomerase ReverseTranscriptase (hTERT)

Melatonin down-regulates hTERT expression induced by either natural estrogens (17beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells.

Cancer Lett. 2008 Sep 18;268(2):272-7.
Martínez-Campa CM, Alonso-González C, Mediavilla MD, Cos S, González A, Sanchez-Barcelo EJ.
Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors.
HumanTelomerase ReverSeTranscriptase (hTERT)

ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration.

J Pineal Res. 2009 Jan;46(1):15-21
Ortíz-López L, Morales-Mulia S, Ramírez-Rodríguez G, Benítez-King G.
Melatonin(1nM) inhibits cancer cell invasion and metastasis formation via ROCK-regulated microfilament and microtubule organization,through increased expression of two cell surface adhesion proteins, E-cadherin and beta(1)-integrin.
Rho-associated proteinkinase (ROCK).

Light at night, chronodisruption, melatonin suppression, and cancer risk: a review

Crit Rev Oncog. 2007 Dec;13(4):303-28
Reiter RJ, Tan DX, Korkmaz A, Erren TC, Piekarski C, Tamura H, Manchester LC.
Both human epidemiological and experimental studies on animals have documented that a potential negative consequence of chronodisruption and nocturnal melatonin inhibition is cancer initiation and growth (breast, prostate, endometrial, and colorectal).
LAN

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