Leucemie Linfomi Mielomi
Anno: 2008
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Riferimento:Hybridoma (Larchmt). 2008 Jun;27(3):205-9.Azione della melatonina:Anti-melatonin monoclonal antibodies (Mab) may be useful for immunoassay of melatonin.Target:Mab-BSA( bovine serum albumin) intraperitonally.
Anno: 2009
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Titolo: sis in B-lymphoma cellsRiferimento:Ann N Y Acad Sci. 2009 Aug;1171:345-9.Azione della melatonina:Melatonin is considered a promising antitumor agent, promoting apoptosis in tumor cells and contrasting it in normal cells.Target:Apoptosis modulator.
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Riferimento:J Pineal Res. 2009 Sep;47(2):147-55.Azione della melatonina:Enhances radiation-induced apoptosis in Jurkat leukemia cells, while reducing radiation-induced apoptosis in normal mice splenocytes.Target:Increase of Bcl-2 expression and a reduction of Bax/Bcl-2 ratio through a relative decrease of p53 mRNA and protein.
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Riferimento:J Pineal Res. 2009 May;46(4):392-400.Azione della melatonina:Has proapoptotic and/or oncostatic effects in the human myeloid cell line HL-60.Target:Treatment (1 mM) induced a significant increase in caspase-3 and -9 activities.
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Riferimento:Cancer Biother Radiopharm. 2009 Jun;24(3):353-5.Azione della melatonina:No patients had disease recurrence, and progression-free survival has not yet been reached (125, 121, 73, and 21 months, respectively).Target:Toxicity was absent, and patients underwent the treatment at home.
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Riferimento:Ann N Y Acad Sci. 2009 Aug;1171:345-9.Azione della melatonina:Stimulate reactive oxygen species (ROS).Target:EBV inhibits melatonin anti-apoptotic effects.
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Riferimento:Ann Ist Super Sanita. 2009;45(3):233-7. Review.Azione della melatonina:50-60 Hz magnetic fields as "possibly carcinogenic to humans" because of the "limited evidence" of carcinogenicity of residential exposure relatively to childhood leukemia, perhaps for subtle differences in the timing of melatonin release.Target:50-60 Hz magnetic fields.
Anno: 2010
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Riferimento:J Pineal Res. 2010 Oct;49(3):283-90.Azione della melatonina:Inhibited DNA damage-induced apoptosis and glutathione (GSH) depletion.Target:TNF-α, TRAIL, anti-Fas antibody or endoplasmic reticulum (ER).
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Riferimento:Radiat Environ Biophys. 2010 Nov;49(4):731-41.Azione della melatonina:Inhibited the MF-induced increase in HSP70.Target:HSP70 protein levels.
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Riferimento:Med Hypotheses. 2010 Sep;75(3):305-11.Azione della melatonina:MLT inhibition increasing the risk of melanoma by increasing circulating oestrogen levels. No studies reporting on the relationship between melanoma and number of sleeping hours, etc.Target:Light-at-night theory (LAN).