Leucemie Linfomi Mielomi
Anno: 2011
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Riferimento:Oncogene advance online publication, 17 October 2011Azione della melatonina:Reduce the risks of developing cancer and preventing DNA damage.Target:Phosphorylation of p53 at Ser-15
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Riferimento:In Vivo. 2011 May-Jun;25(3):405-9.Azione della melatonina:Does not interfere with the cytotoxic effect of cytara-bine, daunorubicin and etoposide in leukemia cells.Target:10(-5) M and 10(-3) M concentrations of MLT.
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Titolo: Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cellsRiferimento:Mol Cell Biochem. 2011 Jul;353(1-2):167-76.Azione della melatonina:Increased the apoptotic effects of H(2)O(2) in human myeloid HL-60 cells.Target:ROS production inducing tumour cell death.
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Riferimento:J Pineal Res. 2011 Apr;50(3):345-55.Azione della melatonina:Induction of cell death in several human malignant haematological cell lines through the activation of the extrinsic pathway of apoptosis.Target:Death receptors Fas, DR4 and DR5 and their ligands Fas L and TRAIL.
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Riferimento:J Pineal Res. 2011 May;50(4):367-73.Azione della melatonina:Significantly augmented the cytotoxicity of puro-mycin in HL-60 cells.Target:AMPK.phosphorylation of 5'-
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Riferimento:Med Pr. 2011;62(3):323-38.Azione della melatonina:A potential link between exposure to light at night and the risk of cancer, indicate that this type of work might lead to circadian disruption, including disruption in the melatonin synthesis.Target:Night shift work.
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Riferimento:In Vivo. 2011 May-Jun;25(3):405-9.Azione della melatonina:Melatonin, 10(-5) M/10(-3) M, does not interfere with the cytotoxic effect of cytarabine, daunorubicin and etoposide in leukemia cells.Target:MLT/chemotherapeutic drugs.
Anno: 2012
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Riferimento:Neuro Endocrinol Lett. 2012 Dec 28;33(8).Azione della melatonina:Observational study on 55 patients affected lymphoma, treated with the Di Bella Method (DBM). The 1, 3 and 5-year survival rates are reported, together with any signs of toxicity. The patients were able to continue the treatment at home, carrying out their normal activities without problems.Target:Di Bella Method (DBM).
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Riferimento:J Pineal Res. 2012 Nov;53(4):366-73.Azione della melatonina:Melatonin could be a potential chemotherapeutic/preventive agent for malignant lymphocytes, where melatonin-induced apoptosis, melatonin can induce caspase activation independent from these receptors.Target:Anti-proliferative/pro-apoptotic effects.
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Riferimento:Am J Epidemiol. 2012 Nov 1;176(9):751-9.Azione della melatonina:Night work may increase cancer risk at several sites among men, possibly via suppression of melatonin release.Target:Night work.