Anno: 2012

• Titolo: Night work and the risk of cancer among men
  Riferimento:

  Am J Epidemiol. 2012 Nov 1;176(9):751-9.
  Azione della melatonina:

  Night work may increase cancer risk at several sites among men, possibly via suppression of melatonin release.
  Target:

  Night work.
• Titolo: Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis
  Riferimento:

  J Pineal Res. 2012 Apr;52(3):322-31.
  Azione della melatonina:

  Melatonin sensitizes human hepatoma cells to ER tress-induced apoptosis by down-regulating COX-2 xpression, incresing the levels of CHOP and decreaing the Bcl-2/Bax ratio.
  Target:

  Endoplasmin reticulum, Cyclooxygenase-2, Pro-apoptotic transcription factor.