Melatonina
Anno: 1997
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Riferimento:Wien Klin Wochenschr. 1997 Oct 3;109(18):722-9. Review. German.Azione della melatonina:Yet unknown chemical structure are capable of inhibiting in vitro cell lines resistant to melatonin.Target:Progressive decline of pineal melatonin secretion.
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Riferimento:J Pineal Res. 1997 Sep;23(2):53-8.Azione della melatonina:Decreased pineal melatonin secretion in breast cancer patients as well as an inverse relationship with tumor-size.Target:6-sulphatoxymelatonin (aMT6s)
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Riferimento:Cancer Res. 1997 May 15;57(10):1909-14.Azione della melatonina:10 microM L-buthionine-[S,R]-sulfoximine(L-BSO) blocks the oncostatic action of 1nM melatonin, glutathione(1microM) is required for melatonin action.Target:Glutathione.
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Riferimento:J Pineal Res. 1997 May;22(4):184-202. Review.Azione della melatonina:Melatonin could indeed be considered a physiological anticancer substance.Target:Antioxidative functions, indirect immunostimulatory effects.
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Riferimento:Support Care Cancer. 1997 Mar;5(2):126-9.Azione della melatonina:Concomitant administration of MLT during chemo-therapy may prevent some chemotherapy-induced side-effects,Target:Influence of MLT on chemotherapy toxicity.
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Riferimento:Bioelectromagnetics. 1997;18(8):555-62.Azione della melatonina:Melatonin (10(-9) M) and tamoxifen (10(-7) M) may act through different biological pathways to down-regulate cell growth.Target:EMF (1.2 microT, 60 Hz).
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Riferimento:Breast Cancer Res Treat. 1997 Jan;42(1):15-22.Azione della melatonina:Breast cancer women had a reversal of the normal seasonal pattern of melatonin secretion.Target:Seasonal variation.
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Riferimento:Cancer Lett. 1997 Jan 1;111(1-2):59-66.Azione della melatonina:Combined therapy of melatonin (200 microg/day, p.o.) and tamoxifen is highly promising in the prophylaxis of breast carcinogenesis in humans.Target:Melatonin/tamoxifen
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Riferimento:J Pineal Res. 1997 Nov;23(4):169-75.Azione della melatonina:Melatonin [(10(-9) M or10(-10) M) for 2 and 5 days] induced very slight alterations in microtubule organization of all cell lines studied.Target:Cytoskeleton.
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Titolo: Effects of melatonin on mammary gland lesions in transgenic mice overexpressing N-ras proto-oncogeneRiferimento:J Pineal Res. 1997 Mar;22(2):86-94.Azione della melatonina:Reduces the incidence of HANs and the expression of N-ras protein in focal hyperplastic lesions.Target:200 microgr/ day, five times a week, i.p.