Melatonina
Anno: 2000
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Riferimento:J Natl Cancer Inst. 2000 May 3;92(9):686-9.Azione della melatonina:Melatonin may act as an antioxidant that can scavenge free radicals and protect against DNA damage.Target:Reduce chemotherapy toxicity.
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Riferimento:Life Sci. 2000 Nov 3;67(24):2953-60.Azione della melatonina:Melatonin (10(-8)-10(-10) M) may be an inhibitor of human mammary and ovarian carcinoma.Target:Pineal substances shown tumor inhibiting activity.
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Riferimento:Front Neuroendocrinol. 2000 Apr;21(2):133-70. Review.Azione della melatonina:The small number of clinical studies focusing on the possible therapeutic value of melatonin (1nM) on breast cancer is surprising.Target:Melatonin's antitumoral actions.
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Titolo: Influence of radiotherapy on 6-sulphatoxymelatonin levels in the urine of brain cancer patients.Riferimento:Neuro Endocrinol Lett. 2000;21(3):203-207.Azione della melatonina:Wide variation in the mean concentration of aMT6S excreted in the urine.Target:6-sulphatoxymelatonin
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Titolo: Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cellsRiferimento:Prostate. 2000 Nov 1;45(3):238-44.Azione della melatonina:Melatonin exerts a direct oncostatic activity on human androgen-independent prostate cancer cells, and on breast cancer.Target:Mel nuclear receptors.
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Riferimento:Epidemiology. 2000 Nov;11(6):660-5.Azione della melatonina:Alcoholic beverages may suppress circulating melatonin levels, and an incrising circulating estrogen could increase the risk of breast cancer.Target:6-sulfatoxymelatonin
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Riferimento:Ann Epidemiol. 2000 Jan;10(1):31-44. Review.Azione della melatonina:EMF and light at night, might contribute to mammary carcinogenesis through inhibition of melatonin.Target:Electromagnetic fields (EMF).
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Titolo: Melatonin effects on intercellular junctional communication in MCF-7 human breast cancer cellsRiferimento:J Pineal Res. 2000 Oct;29(3):166-71.Azione della melatonina:Melatonin (10 microM) could exert its antitumor action by increasing regulatory signals that are passed between adjacent epithelial cells through intercellular junctions.Target:Gap junctional intercellular communication.
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Riferimento:J Pineal Res. 2000 Jan;28(1):41-7.Azione della melatonina:The inclusion of morning urine widespread testing of the role played by melatonin in human health and disease.Target:6-hydroxymelatonin-sulfate (6-OHMS).
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Riferimento:Environ Health Perspect. 2000 Sep;108(9):797-802.Azione della melatonina:These differences include the use of different substrains of Sprague-Dawley rats and differences in MFexposure metrics.Target:50-Hz magnetic field (MF)