Melatonina
Anno: 2010
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Riferimento:Curr Cancer Drug Targets. 2010 May;10(3):279-86.Azione della melatonina:Mlt counteracted the stimulatory effects of estrone sulfate and exert its antitumoral effects by down-re-gulating the sulfatase pathway of the tumoral tissue.Target:Sulfatase-inhibitory properties of melatonin.
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):729-37.Azione della melatonina:Positive association between 6-sulphatoxymelatonin (aMT6s) and risk of breast cancer.Target:aMT6s
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Titolo: Global breast cancer seasonalityRiferimento:Breast Cancer Res Treat. 2010 Aug;123(1):233-43.Azione della melatonina:Breast cancer is consistently diagnosed more often in spring. Its mechanism may depend upon seasonal sunlight mediation of vitamin D and seasonal mediation of nocturnal melatonin peak level and duration.Target:Latitude-dependent breast cancer seasonality.
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Riferimento:J Pineal Res. 2010 Oct;49(3):283-90.Azione della melatonina:Inhibited DNA damage-induced apoptosis and glutathione (GSH) depletion.Target:TNF-α, TRAIL, anti-Fas antibody or endoplasmic reticulum (ER).
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Riferimento:Radiat Environ Biophys. 2010 Nov;49(4):731-41.Azione della melatonina:Inhibited the MF-induced increase in HSP70.Target:HSP70 protein levels.
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Riferimento:Scand J Work Environ Health. 2010 Mar;36(2):163-79.Azione della melatonina:The multilevel endocrine changes caused by circadian disruption with melatonin suppression (LAN) lead to the oncogenic targeting of the endocrine-responsive breast in women and possibly the prostate.Target:LAN
Anno: 2011
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Riferimento:J Pineal Res. 2011 Oct;51(3):345-52.Azione della melatonina:MLT may modulate miRNA and gene expression as an anticancer mechanism in MCF-7 human breast cancer cells.Target:MicroRNAs (miRNAs).
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Riferimento:J Pineal Res. 2011 Oct;51(3):259-69.Azione della melatonina:Down-regulation of 13-HODE reduces the activation of growth factor pathways supporting cell proliferation and survival.Target:3-hydroxyoctadecadie-noic acid (13-HODE).
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Riferimento:J Recept Signal Transduct Res. 2011 Apr;31(2):180-7.Azione della melatonina:The low expression of CYP1A1 or CYP1A2 in breast cancer specimens suggested that melatonin might be involved in cell cycle arrest.Target:CYP1A1/1A2, SULT1A1/1A3/1E1, cyclin D1.
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Riferimento:Med Pr. 2011;62(3):323-38.Azione della melatonina:A potential link between exposure to light at night and the risk of cancer, indicate that this type of work might lead to circadian disruption, including disruption in the melatonin synthesis.Target:Night shift work.