Melatonina
Anno: 2011
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Riferimento:Med Pr. 2011;62(3):323-38.Azione della melatonina:A potential link between exposure to light at night and the risk of cancer, indicate that this type of work might lead to circadian disruption, including disruption in the melatonin synthesis.Target:Night shift work.
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Riferimento:J Pineal Res. 2011 Mar;50(2):150-8.Azione della melatonina:Cytostatic effects triggered by melatonin and D3 are likely related to a complex TGFβ-1-dependent mechanism, involving down-regulation of both MDM2 and Akt-phosphorylation.Target:p53/MDM2 ratio.
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Riferimento:J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):531-42.Azione della melatonina:Decreased expression of MT1 in human colorectal cancer could point to a role of melatonin in this disease.Target:Melatonin receptor 1 (MT1)
Anno: 2012
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Riferimento:Eur J Pharmacol. 2012 Apr 15;681(1-3):34-43.Azione della melatonina:Administration of melatonin with all-trans retinoic acid and somatostatin may be of significant therapeutic benefit in breast cancer.Target:Melatonin effects potentiated
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Riferimento:Scand J Work Environ Health. 2012 Jul 1;38(4):380-90.Azione della melatonina:Elevations in risk of breast cancer after about 20 years working night shift. Accelerated tumor growth by suppression of melatonin secretion.Target:Shift work carcinogenic to humans (group 2A).
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Riferimento:Expert Opin Investig Drugs. 2012 Jun;21(6):819-31.Azione della melatonina:Melatonin could be an excellent adjuvant with the drugs currently used for breast cancer prevention.Target:Selective estrogen receptor/enzyme modulators
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Riferimento:J Pineal Res. 2012 Aug;53(1):77-90.Azione della melatonina:Inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-κB and PI3K/Akt/signaling and activating the Apaf-1/ caspase-dependent apoptotic pathway.Target:Mlt 10(-3)M
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Riferimento:Mol Carcinog. 2012 Aug;51(8):608-18.Azione della melatonina:Melatonin inhibits growth and invasive capacity of colon cancer cells in vitro through its membrane (MT1 and MT2) and/or nuclear receptors (RORα).Target:MT1- MT2 - RORα
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):609-18.Azione della melatonina:Night shift work may disrupt the normal nocturnal rise in melatonin, resulting in increased breast cancer risk.Target:Reduced 6-sulfatoxymelatonin levels during night work and daytime sleep.
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Riferimento:BMJ Open. 2012 Jan 21;2(1).Azione della melatonina:Inverse relationship between aMTs-6(6-sulfatoxymelatonin) and oestradiol was suggested in the winter.Target:Long-term shift work as a probable carcinogen.