Melatonina
Anno: 2012
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Riferimento:Cell Mol Life Sci. 2012 Sep 25.Azione della melatonina:Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.Target:Melatonin acts at different physiological levels.
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Riferimento:J Pineal Res. 2012 Aug 16.Azione della melatonina:Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.Target:Vascular endothelial growth factor (VEGF)
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Riferimento:J Pineal Res. 2012 Jan;52(1):12-20.Azione della melatonina:Mlt (1mM) could stimulate the differentiation of preadipocytes (3T3-L1) into adipocytes.Target:3T3-L1 adipocytes.
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Riferimento:Mol Endocrinol. 2012 Nov;26(11):1808-20.Azione della melatonina:Melatonin activates GSK3β by inhibiting epithelial-to-mesenchymal transition, a fundamental process underlying cancer metastasis.Target:Glycogen synthase kinase 3β (GSK3β)
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Riferimento:Breast Cancer (Auckl). 2012;6:137-50.Azione della melatonina:Melatonin administration following serum shock differentially suppressed or induced clock gene (Bmal1 and Per2) and CCG expression in MCF10A and MCF-7 cells.Target:Clock and clock-controlled genes (CCGs)
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Riferimento:J Pineal Res. 2012 Jun 27.Azione della melatonina:DNA methylation patterns induced by melatonin (1nm) suggest a potential mechanism of the anticancer effect in melatonin-treated breast cancer cells.Target:DNA methylation
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Riferimento:Am J Epidemiol. 2012 Nov 1;176(9):751-9.Azione della melatonina:Night work may increase cancer risk at several sites among men, possibly via suppression of melatonin release.Target:Night work.
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Riferimento:J Appl Toxicol. 2012 Dec;32(12):952-8.Azione della melatonina:Study on disruption of circadian rhythmicity in humans (children if possible) under long-term exposure to weak ELF MF.Target:Extremely low-frequency (ELF) magnetic fields (MF)
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Riferimento:J Pineal Res. 2012 Apr;52(3):322-31.Azione della melatonina:Melatonin sensitizes human hepatoma cells to ER tress-induced apoptosis by down-regulating COX-2 xpression, incresing the levels of CHOP and decreaing the Bcl-2/Bax ratio.Target:Endoplasmin reticulum, Cyclooxygenase-2, Pro-apoptotic transcription factor.
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Riferimento:Recent Pat Anticancer Drug Discov. 2012 Sep;7(3):337-44.Azione della melatonina:Systemic effects of darkness and excessive melatonin synthesis enables cancer protection treatment for people living in light-deficient environment.Target:Racial/ethnic disparities