Melatonina
Anno: 2012
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Titolo: Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine productionRiferimento:J Pineal Res. 2012 Apr;52(3):282-90.Azione della melatonina:One millimolar melatonin induced a reduction in TNF-α, IL-6, and IL-11 mRNA expression in MCF-7 and 3T3-L1 cells.Target:Aromatase enzyme,tumor necrosis factor (TNF)-α, interleukin (IL)-11 and interleukin (IL)-6.
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Riferimento:Klin Onkol. 2012;25(5):359-63.Azione della melatonina:Melatonin ( 4 times a week,20 μg/ml of drinking water) significantly reduced tumor volume in comparison with control animals.Target:Chemoprevention
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Riferimento:J Pineal Res. 2012 Nov;53(4):366-73.Azione della melatonina:Melatonin could be a potential chemotherapeutic/preventive agent for malignant lymphocytes, where melatonin-induced apoptosis, melatonin can induce caspase activation independent from these receptors.Target:Anti-proliferative/pro-apoptotic effects.
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Riferimento:Breast Cancer Res Treat. 2012 Apr;132(2):693-9.Azione della melatonina:Genetic variation in the MTNR1a and 1b genes may contribute to breast cancer, no breast cancer associations were found for variants in the AANAT gene.Target:Mlt receptors 1a and 1b (MTNR1a and MTNR1b), arylalkylamine N-acetyl-transferase (AANAT).
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Riferimento:Am J Epidemiol. 2012 Nov 1;176(9):760-3.Azione della melatonina:Direct oncostatic properties of melatonin in shift-work-cancer association.Target:Night-shift work
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Riferimento:Eur J Cancer Prev. 2012 Mar;21(2):163-70.Azione della melatonina:Resveratrol in combination with melatonin has some protective effects on N-methyl-N-nitrosourea (NMU)-induced rodent breast cancer.Target:Chemoprevention with resveratrol and mlt.
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Riferimento:J Pineal Res. 2012 Aug 16.Azione della melatonina:Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.Target:Vascular endothelial growth factor (VEGF)
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Riferimento:Cell Mol Life Sci. 2012 Sep 25.Azione della melatonina:Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.Target:Melatonin acts at different physiological levels.
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Riferimento:Breast Cancer (Auckl). 2012;6:137-50.Azione della melatonina:Melatonin administration following serum shock differentially suppressed or induced clock gene (Bmal1 and Per2) and CCG expression in MCF10A and MCF-7 cells.Target:Clock and clock-controlled genes (CCGs)
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Riferimento:J Pineal Res. 2012 Jan;52(1):12-20.Azione della melatonina:Mlt (1mM) could stimulate the differentiation of preadipocytes (3T3-L1) into adipocytes.Target:3T3-L1 adipocytes.