Melatonina

Target

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Azione della melatonina

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Anno: 2012

Titolo: Oscillation of clock and clock controlled genes induced by serum shock in human breast epithelial and breast cancer cells: regulation by melatonin

Riferimento:
Breast Cancer (Auckl). 2012;6:137-50.

Azione della melatonina:
Melatonin administration following serum shock differentially suppressed or induced clock gene (Bmal1 and Per2) and CCG expression in MCF10A and MCF-7 cells.

Target:
Clock and clock-controlled genes (CCGs)
Titolo: Genome-wide profiling in melatonin-exposed human breast cancer cell lines identifies differentially methylated genes involved in the anticancer effect of melatonin

Riferimento:
J Pineal Res. 2012 Jun 27.

Azione della melatonina:
DNA methylation patterns induced by melatonin (1nm) suggest a potential mechanism of the anticancer effect in melatonin-treated breast cancer cells.

Target:
DNA methylation
Titolo: Night work and the risk of cancer among men

Riferimento:
Am J Epidemiol. 2012 Nov 1;176(9):751-9.

Azione della melatonina:
Night work may increase cancer risk at several sites among men, possibly via suppression of melatonin release.

Target:
Night work.
Titolo: Health effects of extremely low-frequency magnetic fields: reconsidering the melatonin hypothesis in the light of current data on magnetoreception

Riferimento:
J Appl Toxicol. 2012 Dec;32(12):952-8.

Azione della melatonina:
Study on disruption of circadian rhythmicity in humans (children if possible) under long-term exposure to weak ELF MF.

Target:
Extremely low-frequency (ELF) magnetic fields (MF)
Titolo: Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis

Riferimento:
J Pineal Res. 2012 Apr;52(3):322-31.

Azione della melatonina:
Melatonin sensitizes human hepatoma cells to ER tress-induced apoptosis by down-regulating COX-2 xpression, incresing the levels of CHOP and decreaing the Bcl-2/Bax ratio.

Target:
Endoplasmin reticulum, Cyclooxygenase-2, Pro-apoptotic transcription factor.
Titolo: Light deficiency confers breast cancer risk by endocrine disorders.

Riferimento:
Recent Pat Anticancer Drug Discov. 2012 Sep;7(3):337-44.

Azione della melatonina:
Systemic effects of darkness and excessive melatonin synthesis enables cancer protection treatment for people living in light-deficient environment.

Target:
Racial/ethnic disparities

Anno: 2013

Titolo: Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathw

Riferimento:
BMC Cell Biol. 2013 Jan 7;14:1.

Azione della melatonina:
Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.

Target:
DNA repair capacity
Titolo: Expression of melatonin receptors in triple negative breast cancer (TNBC) in African American and Caucasian women: relation to survival

Riferimento:
Breast Cancer Res Treat. 2013 Feb;137(3):677-87.

Azione della melatonina:
Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.

Target:
TNBC

A.I.A.N. - Modena

Melatonina

Anno: 2012

Anno: 2013

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