Melatonina

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Azione della melatonina

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Anno: 1993

Titolo: Selective effect of melatonin on the proliferation of lymphoid cells

Riferimento:
Int J Biochem. 1993 Mar;25(3):441-4.

Azione della melatonina:
Affect selectively the processes of lymphoblastoid cell growth.

Target:
200 microM in vitro.
Titolo: Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract

Riferimento:
Br J Cancer.1993 Jun;67(6):1404-7.

Azione della melatonina:
The immunotherapy with low-dose IL-2 plus MLT (50mg/day orally) is a new well tolerated and effective therapy of advanced tumours of digestive tract.

Target:
Interleukin 2 (IL-2) plus MLT.

Anno: 1994

Titolo: Serial transplants of 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Fischer rats as model system for human breast cancer. 3. Quantitative ultrastructural studies of the pinealocytes and plasma melatonin concentrations in rats bearing an advance

Riferimento:
Biol Signals. 1994 Nov-Dec;3(6):302-6.

Azione della melatonina:
Plasma melatonin concentrations in tumor-bearing rats killed at 3.00 h were suppressed by 35% when compared to the control animals killed at the same time.

Target:
Plasma melatonin concentrations
Titolo: Differences between pulsatile or continuous exposure to melatonin on MCF-7 human breast cancer cell proliferation

Riferimento:
Cancer Lett. 1994 Sep 30;85(1):105-9.

Azione della melatonina:
Antiproliferative effect was obtained by sequential exposure to 10(-9) M/10(-11)M 12/12h melatonin, which mimics the physiological rhythm of serum melatonin concentration.

Target:
Physiological rhythm/serum melatonin concentration
Titolo: Melatonin modulates growth factor activity in MCF-7 human breast cancer cells

Riferimento:
J Pineal Res. 1994 Aug;17(1):25-32.

Azione della melatonina:
Melatonin(10(-9)M) may inhibit the action and/or release of growth stimulatory factors as well as stimulate the release of growth inhibitory factors.

Target:
Epidermal growth factor (EGF)
Titolo: Breast cancer mortality among female electrical workers in the United States

Riferimento:
J Natl Cancer Inst. 1994 Jun 15;86(12):921-5.

Azione della melatonina:
Exposure to extremely low-frequency electromagnetic fields reduces the production of melatonin.

Target:
ELF
Titolo: Diminished pineal function coincides with disturbed circadian endocrine rhythmicity in untreated primary cancer patients. Consequence of premature aging or of tumor growth?

Riferimento:
Ann N Y Acad Sci. 1994 May 31;719:502-25. Review.

Azione della melatonina:
No abstract available.

Target:
No abstract available.
Titolo: 5-Fluorouracil attenuates an oncostatic effect of melatonin on estrogen-sensitive human breast cancer cells (MCF7)

Riferimento:
Cancer Lett. 1994 Jun 15;81(1):95-8.

Azione della melatonina:
Melatonin(0,3nM)inhibited MCF7 cell growth, effect of melatonin was reduced by the co-administration of 5-FU.

Target:
5-fluorouracil (5-FU)
Titolo: Effects of weak alternating magnetic fields on nocturnal melatonin production and mammary carcinogenesis in rats

Riferimento:
Oncology. 1994 May-Jun;51(3):288-95.

Azione della melatonina:
Nocturnal melatonin levels were significantly reduced by exposure to this weak alternating MF.

Target:
Magnetic fields (MFs)
Titolo: Interaction between melatonin and estradiol on morphological and morphometric features of MCF-7 human breast cancer cells

Riferimento:
J Pineal Res. 1994 May;16(4):215-22.

Azione della melatonina:
Antitumor effect through a cell-cycle-specific mechanism by delaying the entry of cells into mitosis.

Target:
Smaller cell and nuclear sizes

A.I.A.N. - Modena

Melatonina

Anno: 1993

Anno: 1994

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