Melatonina
Anno: 1993
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Riferimento:Environ Health Perspect. 1993 Dec;101 Suppl 4:93-100.Azione della melatonina:Effects on: DNA transcription and translation, calcium balance in cells, pineal production of mlt.Target:Electromagnetic fields (EMF)
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Riferimento:Int J Oncol. 1993 Oct;3(4):687-94.Azione della melatonina:Antimitotic actions of melatonin(10(-8)-10(-11) M) may be mediated through the suppression of the estrogen-response pathway of MCF-7 cells.Target:Estrogen receptor (ER)
Anno: 1994
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Riferimento:Br J Cancer. 1994 Jan;69(1):196-9.Azione della melatonina:The concomitant administration of MLT (40 mg day orally) may increase the efficacy of low-dose IL-2 subcutaneous therapy.Tumour objective regression rate was 11/41 vs 1/39, P < 0.001.Target:Interleukin 2 (IL-2) plus MLT.
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Titolo: Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells.Riferimento:Mol Endocrinol. 1994 Dec;8(12):1681-90.Azione della melatonina:Antiproliferative actions of Mlt are mediated through the suppression of the transcription of ER gene.Target:Estrogen receptor (ER) mRNA
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Riferimento:Biol Signals. 1994 Nov-Dec;3(6):302-6.Azione della melatonina:Plasma melatonin concentrations in tumor-bearing rats killed at 3.00 h were suppressed by 35% when compared to the control animals killed at the same time.Target:Plasma melatonin concentrations
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Riferimento:Cancer Lett. 1994 Sep 30;85(1):105-9.Azione della melatonina:Antiproliferative effect was obtained by sequential exposure to 10(-9) M/10(-11)M 12/12h melatonin, which mimics the physiological rhythm of serum melatonin concentration.Target:Physiological rhythm/serum melatonin concentration
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Riferimento:J Pineal Res. 1994 Aug;17(1):25-32.Azione della melatonina:Melatonin(10(-9)M) may inhibit the action and/or release of growth stimulatory factors as well as stimulate the release of growth inhibitory factors.Target:Epidermal growth factor (EGF)
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Riferimento:J Natl Cancer Inst. 1994 Jun 15;86(12):921-5.Azione della melatonina:Exposure to extremely low-frequency electromagnetic fields reduces the production of melatonin.Target:ELF
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Riferimento:Ann N Y Acad Sci. 1994 May 31;719:502-25. Review.Azione della melatonina:No abstract available.Target:No abstract available.
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Riferimento:Cancer Lett. 1994 Jun 15;81(1):95-8.Azione della melatonina:Melatonin(0,3nM)inhibited MCF7 cell growth, effect of melatonin was reduced by the co-administration of 5-FU.Target:5-fluorouracil (5-FU)