Melatonina

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Azione della melatonina

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Anno: 1993

Titolo: Neuroimmunotherapy of advanced solid neoplasms with single evening subcutaneous injection of low-dose interleukin-2 and melatonin: preliminary results

Riferimento:
Eur J Cancer. 1993;29A(2):185-9.

Azione della melatonina:
Neuroimmunotherapy with low-dose IL-2 and MLT (50mg/day orally) is a biologically active and well tolerated strategy, capable of determining an apparent control of tumour growth in patients with advanced solid neoplasms.

Target:
Interleukin 2 (IL-2) plus .MLT
Titolo: Vitiligo: where do we stand?

Riferimento:
Pigment Cell Res. 1993 Mar;6(2):61-72.

Azione della melatonina:
Abnormalities in a putative melatonin receptor on melanocytes.

Target:
Several different pathogenetic mechanisms.

Anno: 1994

Titolo: 5-Fluorouracil attenuates an oncostatic effect of melatonin on estrogen-sensitive human breast cancer cells (MCF7)

Riferimento:
Cancer Lett. 1994 Jun 15;81(1):95-8.

Azione della melatonina:
Melatonin(0,3nM)inhibited MCF7 cell growth, effect of melatonin was reduced by the co-administration of 5-FU.

Target:
5-fluorouracil (5-FU)
Titolo: Effects of weak alternating magnetic fields on nocturnal melatonin production and mammary carcinogenesis in rats

Riferimento:
Oncology. 1994 May-Jun;51(3):288-95.

Azione della melatonina:
Nocturnal melatonin levels were significantly reduced by exposure to this weak alternating MF.

Target:
Magnetic fields (MFs)
Titolo: Interaction between melatonin and estradiol on morphological and morphometric features of MCF-7 human breast cancer cells

Riferimento:
J Pineal Res. 1994 May;16(4):215-22.

Azione della melatonina:
Antitumor effect through a cell-cycle-specific mechanism by delaying the entry of cells into mitosis.

Target:
Smaller cell and nuclear sizes
Titolo: Animal studies on the role of 50/60-Hertz magnetic fields in carcinogenesis

Riferimento:
Life Sci. 1994;54(21):1531-43. Review.

Azione della melatonina:
Reduction of circulating levels of melatonin.

Target:
50/60-Hz MF
Titolo: Melatonin concentrations in pineal organ culture are suppressed by sera from tumor-bearing mice

Riferimento:
J Pineal Res. 1994 Aug;17(1):17-9.

Azione della melatonina:
Melatonin rhythmicity is suppressed in cancer patients.

Target:
Plasma borne tumor-associated factor (TAMF).
Titolo: Breast cancer mortality among female electrical workers in the United States

Riferimento:
J Natl Cancer Inst. 1994 Jun 15;86(12):921-5.

Azione della melatonina:
Exposure to extremely low-frequency electromagnetic fields reduces the pineal gland's nocturnal production of the hormone melatonin.

Target:
Electric or magnetic fields.
Titolo: A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma

Riferimento:
Br J Cancer. 1994 Jan;69(1):196-9.

Azione della melatonina:
The concomitant administration of MLT (40 mg day orally) may increase the efficacy of low-dose IL-2 subcutaneous therapy.Tumour objective regression rate was 11/41 vs 1/39, P < 0.001.

Target:
Interleukin 2 (IL-2) plus MLT.
Titolo: Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells.

Riferimento:
Mol Endocrinol. 1994 Dec;8(12):1681-90.

Azione della melatonina:
Antiproliferative actions of Mlt are mediated through the suppression of the transcription of ER gene.

Target:
Estrogen receptor (ER) mRNA

A.I.A.N. - Modena

Melatonina

Anno: 1993

Anno: 1994

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