Neoplasie della mammella

Target

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Azione della melatonina

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Anno: 1988

Titolo: Inhibition of Dunning tumor growth by melatonin

Riferimento:
J Urol. 1988 May;139(5):1099-102.

Azione della melatonina:
MCF breast cancer tissue indicate an estrogen requirement for inhibition of growth by melatonin.

Target:
Inhibit tumor growth
Titolo: Neuroimmunomodulation in cancer patients: correlations between melatonin and beta-endorphin blood levels and T helper/suppressor ratio

Riferimento:
Int J Biol Markers. 1988 Apr-Jun;3(2):82-6.

Azione della melatonina:
Metastatic patients had lower melatonin levels and a lower T4/T8 ratio.

Target:
MLT/ beta-endorphin

Anno: 1989

Titolo: Alterations of pineal gland and of T lymphocyte subsets in metastatic cancer patients: preliminary results

Riferimento:
J Biol Regul Homeost Agents. 1989 Oct-Dec;3(4):181-3.

Azione della melatonina:
Serum levels of MLT were higher in patients with low CD4/CD8 ratio than in normal ratio.

Target:
T helper/suppressor ratio (CD4/CD8)
Titolo: Melatonin and steroid-dependent carcinomas

Riferimento:
Andrologia. 1989 Sep-Oct;21(5):429-31.

Azione della melatonina:
Melatonin level was lower in patients with breast cancer as compared to controls.

Target:
MLT play a role in breast carcinoma
Titolo: Stage-dependent depression of melatonin in patients with primary breast cancer. Correlation with prolactin, thyroid stimulating hormone, and steroid receptors

Riferimento:
Cancer. 1989 Jul 15;64(2):426-33.

Azione della melatonina:
Direct involvement of melatonin in the growth control of breast cancer.

Target:
Progesterone/androgen receptors
Titolo: The pineal gland and breast cancer: serum levels of melatonin in patients with mammary tumors and their relation to clinical characteristics

Riferimento:
Int J Biol Markers. 1989 Jul-Sep;4(3):157-62.

Azione della melatonina:
Melatonin concentrations were highest in breast cancer patients with the best prognosis.

Target:
Estrogen receptor-posit.

Anno: 1990

Titolo: Pineal gland and tumor cell kinetics: serum levels of melatonin in relation to Ki-67 labeling rate in breast cancer

Riferimento:
Oncology. 1990;47(3):275-7.

Azione della melatonina:
Breast cancer patients showed significantly higher mean values of melatonin than controls.

Target:
Antineoplastic role
Titolo: Non parametric testing of melatonin characteristics as potential markers of breast cancer risk

Riferimento:
Prog Clin Biol Res. 1990;341A:21-30.

Azione della melatonina:
The re-evaluation of ML data by BS provides statistical validation of a test battery for breast cancer risk.

Target:
Bubble Sort (BS)
Titolo: Plasma melatonin in patients with breast cancer

Riferimento:
Oncology. 1990;47(5):401-5.

Azione della melatonina:
Multiple-regression tests showed a inverse correlation between survival and melatonin values.

Target:
Daytime plasma melatonin values
Titolo: Oncostatic effects of the pineal gland

Riferimento:
Drug Metabol Drug Interact. 1990;8(3-4):313-9. Review.

Azione della melatonina:
Melatonin receptors are the sites of interaction between melatonin and the tumor cell.

Target:
Melatonin receptor

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