Neoplasie della mammella
Anno: 1994
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Riferimento:J Pineal Res. 1994 May;16(4):215-22.Azione della melatonina:Antitumor effect through a cell-cycle-specific mechanism by delaying the entry of cells into mitosis.Target:Smaller cell and nuclear sizes
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Riferimento:Life Sci. 1994;54(21):1531-43. Review.Azione della melatonina:Reduction of circulating levels of melatonin.Target:50/60-Hz MF
Anno: 1995
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Titolo: The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytesRiferimento:J Biol Chem. 1995 Mar 31;270(13):7037-40.Azione della melatonina:5-lipoxygenase is the natural RZR alpha responding gene.New perspective in the involvement of MLT in inflammatory and immunological reactions.Target:Retinoid Z receptor (RZR alpha and beta)
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Riferimento:Breast Cancer Res Treat. 1995 Mar;33(3):257-64.Azione della melatonina:Melatonin/ovarian-steroid contraceptive will restore the lost mechanism of endogenous anovulation.Target:Seasonal ovulation
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Riferimento:J Pineal Res. 1995 Mar;18(2):93-103.Azione della melatonina:Melatonin (10(-9) M) induces growth inhibition in breast tumor cells.Target:Estrogen receptor (ER)
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Riferimento:Med Hypotheses. 1995 Jan;44(1):39-46.Azione della melatonina:Mindfulness meditation is associated with increased physiological levels of melatonin.Target:Effect of meditation on 6-sulphatoxymelatonin
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Riferimento:Carcinogenesis. 1995 Dec;16(12):2945-9.Azione della melatonina:Oncostatic action of melatonin[10(-10) M]is exerted through modulation of the levels of gap junctional intercellular communication. Also, the data indicate that ELF-MF could counteract the melatonin-induced enhancement of junctional transfer.Target:Extremely low frequency (ELF magnetic fields(MF)
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Titolo: Melatoni blocks the stimulatory effects of prolactin on human breast cancer cell growth in cultureRiferimento:Br J Cancer. 1995 Dec;72(6):1435-40.Azione della melatonina:Mlt interrupts the PRL receptor (PRLR)-mediated growth signal in HBC and suggest that the oncostatic activity of Mlt may also be linked with an antagonism of PRL's actions.Target:Monoclonal antibodies (Mabs) against PRLR
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Riferimento:Oncol Rep. 1995 Nov;2(6):1063-8.Azione della melatonina:Induce objective tumor regressions in most advanced solid tumor histotypes by low-dose IL-2 plus MLT (orally at 40 mg/day).Target:Interleukin-2 (IL.2)
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Riferimento:Oncol Rep. 1995 Sep;2(5):871-3.Azione della melatonina:Association of MLT(20 mg/day orally) may make TMX effective also in ER-negative metastatic breast cancer patients.Target:Tamoxifen (TMX) Melatonin(MLT) Estrogen receptor (ER)