Neoplasie della mammella
Anno: 1995
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Riferimento:Carcinogenesis. 1995 Dec;16(12):2945-9.Azione della melatonina:Oncostatic action of melatonin[10(-10) M]is exerted through modulation of the levels of gap junctional intercellular communication. Also, the data indicate that ELF-MF could counteract the melatonin-induced enhancement of junctional transfer.Target:Extremely low frequency (ELF magnetic fields(MF)
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Titolo: Melatoni blocks the stimulatory effects of prolactin on human breast cancer cell growth in cultureRiferimento:Br J Cancer. 1995 Dec;72(6):1435-40.Azione della melatonina:Mlt interrupts the PRL receptor (PRLR)-mediated growth signal in HBC and suggest that the oncostatic activity of Mlt may also be linked with an antagonism of PRL's actions.Target:Monoclonal antibodies (Mabs) against PRLR
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Riferimento:Oncol Rep. 1995 Nov;2(6):1063-8.Azione della melatonina:Induce objective tumor regressions in most advanced solid tumor histotypes by low-dose IL-2 plus MLT (orally at 40 mg/day).Target:Interleukin-2 (IL.2)
Anno: 1996
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Riferimento:Br J Cancer. 1996 Nov;74(9):1466-8.Azione della melatonina:Combination with Tamoxifene plus Melatonin (20 mg day) may have some benefit in untreatable metastatic solid tumour patients.Target:Melatonin/tamoxifen
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Titolo: Melatonin in human breast cancer tissue: association with nuclear grade and estrogen receptor statusRiferimento:Lab Invest. 1996 Oct;75(4):557-61.Azione della melatonina:ExogenousMLT may influence nuclear grade and/or estrogen receptor activity in breast cancer patients.Target:Nuclear grade/melatonin
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Riferimento:J Pineal Res. 1996 Apr;20(3):173.Azione della melatonina:No abstract available.Target:No abstract available.
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Riferimento:J Toxicol Environ Health. 1996 Jun 7;48(2):169-85.Azione della melatonina:50-Hz, 100-mG MF significantly decreases circulating melatonin but is not associated with a development of DMBA-induced mammary tumors.Target:Dimethylbenzanthracene (DMBA) Magnetic field (MF)
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Riferimento:Life Sci. 1996 May 24;58(26):2447-53.Azione della melatonina:Melatonin (1nM) antiproliferative effects could be mediated by a reduction of DNA synthesis.Target:Mitotic block in S phase
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Riferimento:Carcinogenesis. 1996 May;17(5):903-10.Azione della melatonina:Nocturnal serum melatonin determination at 50 microT did not yield significant differences.Target:Magnetic fields (MF) Dimethylbenzanthracene (DMBA)
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Riferimento:Cancer Causes Control. 1996 Mar;7(2):197-204.Azione della melatonina:Results support an association between work as a radio and telegraph operator and breast cancer for disturbances of chronobiological parameters.Target:Decrement of melatonin