Neoplasie della mammella
Anno: 1996
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Riferimento:Life Sci. 1996 May 24;58(26):2447-53.Azione della melatonina:Melatonin (1nM) antiproliferative effects could be mediated by a reduction of DNA synthesis.Target:Mitotic block in S phase
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Riferimento:Carcinogenesis. 1996 May;17(5):903-10.Azione della melatonina:Nocturnal serum melatonin determination at 50 microT did not yield significant differences.Target:Magnetic fields (MF) Dimethylbenzanthracene (DMBA)
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Riferimento:Cancer Causes Control. 1996 Mar;7(2):197-204.Azione della melatonina:Results support an association between work as a radio and telegraph operator and breast cancer for disturbances of chronobiological parameters.Target:Decrement of melatonin
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Riferimento:Environ Health Perspect. 1996 Mar;104 Suppl 1:135-40. Review.Azione della melatonina:Light and EMF effects on melatonin; melatonin effects on breast cancer.Target:Light at night (LAN),ele-ctromagnetic fields(EMF)
Anno: 1997
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Riferimento:Wien Klin Wochenschr. 1997 Oct 3;109(18):722-9. Review. German.Azione della melatonina:Yet unknown chemical structure are capable of inhibiting in vitro cell lines resistant to melatonin.Target:Progressive decline of pineal melatonin secretion.
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Riferimento:J Pineal Res. 1997 Sep;23(2):53-8.Azione della melatonina:Decreased pineal melatonin secretion in breast cancer patients as well as an inverse relationship with tumor-size.Target:6-sulphatoxymelatonin (aMT6s)
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Riferimento:Cancer Res. 1997 May 15;57(10):1909-14.Azione della melatonina:10 microM L-buthionine-[S,R]-sulfoximine(L-BSO) blocks the oncostatic action of 1nM melatonin, glutathione(1microM) is required for melatonin action.Target:Glutathione.
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Riferimento:J Pineal Res. 1997 May;22(4):184-202. Review.Azione della melatonina:Melatonin could indeed be considered a physiological anticancer substance.Target:Antioxidative functions, indirect immunostimulatory effects.
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Riferimento:Support Care Cancer. 1997 Mar;5(2):126-9.Azione della melatonina:Concomitant administration of MLT during chemo-therapy may prevent some chemotherapy-induced side-effects,Target:Influence of MLT on chemotherapy toxicity.
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Riferimento:Bioelectromagnetics. 1997;18(8):555-62.Azione della melatonina:Melatonin (10(-9) M) and tamoxifen (10(-7) M) may act through different biological pathways to down-regulate cell growth.Target:EMF (1.2 microT, 60 Hz).