Neoplasie della mammella
Anno: 1996
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Riferimento:Environ Health Perspect. 1996 Mar;104 Suppl 1:135-40. Review.Azione della melatonina:Light and EMF effects on melatonin; melatonin effects on breast cancer.Target:Light at night (LAN),ele-ctromagnetic fields(EMF)
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Riferimento:Int J Occup Environ Health. 1996 Jan;2(1):37-47.Azione della melatonina:Associations between EMF exposure, breast cancer and modifications of melatonin secretion could be a biologic signal of these effects.Target:50/60-Hz electric and magnetic fields (EMF)
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Riferimento:Bioelectromagnetics. 1996;17(5):396-405.Azione della melatonina:Effects of light and electromagnetic fields (EMFs) could have implications for long-term risk of breast cancer, peak levels may be consistent with those thought to suppress melatonin.Target:Light and electromagnetic fields (EMFs)
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Titolo: Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatoninRiferimento:Life Sci. 1996;58(9):811-6.Azione della melatonina:Melatonin,(10(-9)M) added to the culture medium, increased the duration of the cell cycle of human breast cancer cells, delaying the entry into mitosis.Target:Melatonin inhibitory effect
Anno: 1997
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Riferimento:J Pineal Res. 1997 Nov;23(4):169-75.Azione della melatonina:Melatonin [(10(-9) M or10(-10) M) for 2 and 5 days] induced very slight alterations in microtubule organization of all cell lines studied.Target:Cytoskeleton.
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Riferimento:Pharmacol Toxicol. 1997 Dec;81(6):265-70.Azione della melatonina:Seasonal variation in the development and growth of DMBA-induced breast cancer as the seasonal variation in pineal melatonin production.Target:Circannual rhythms.
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Riferimento:Wien Klin Wochenschr. 1997 Oct 3;109(18):722-9. Review. German.Azione della melatonina:Yet unknown chemical structure are capable of inhibiting in vitro cell lines resistant to melatonin.Target:Progressive decline of pineal melatonin secretion.
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Riferimento:J Pineal Res. 1997 Sep;23(2):53-8.Azione della melatonina:Decreased pineal melatonin secretion in breast cancer patients as well as an inverse relationship with tumor-size.Target:6-sulphatoxymelatonin (aMT6s)
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Riferimento:Cancer Res. 1997 May 15;57(10):1909-14.Azione della melatonina:10 microM L-buthionine-[S,R]-sulfoximine(L-BSO) blocks the oncostatic action of 1nM melatonin, glutathione(1microM) is required for melatonin action.Target:Glutathione.
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Riferimento:J Pineal Res. 1997 May;22(4):184-202. Review.Azione della melatonina:Melatonin could indeed be considered a physiological anticancer substance.Target:Antioxidative functions, indirect immunostimulatory effects.