Melatonina
Anno: 2000
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Riferimento:Br J Cancer. 2001 Feb 2;84(3):397-9.Azione della melatonina:Our findings give support to the 'melatonin hypothesis'.Target:Visually impaired women.
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Riferimento:Front Neuroendocrinol. 2000 Apr;21(2):133-70. Review.Azione della melatonina:The small number of clinical studies focusing on the possible therapeutic value of melatonin (1nM) on breast cancer is surprising.Target:Melatonin's antitumoral actions.
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Riferimento:Life Sci. 2000 Nov 3;67(24):2953-60.Azione della melatonina:Melatonin (10(-8)-10(-10) M) may be an inhibitor of human mammary and ovarian carcinoma.Target:Pineal substances shown tumor inhibiting activity.
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Titolo: Influence of radiotherapy on 6-sulphatoxymelatonin levels in the urine of brain cancer patients.Riferimento:Neuro Endocrinol Lett. 2000;21(3):203-207.Azione della melatonina:Wide variation in the mean concentration of aMT6S excreted in the urine.Target:6-sulphatoxymelatonin
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Titolo: Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cellsRiferimento:Prostate. 2000 Nov 1;45(3):238-44.Azione della melatonina:Melatonin exerts a direct oncostatic activity on human androgen-independent prostate cancer cells, and on breast cancer.Target:Mel nuclear receptors.
Anno: 2001
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Riferimento:J Pineal Res. 2001 Oct;31(3):206-13.Azione della melatonina:In the concentration range 10-2000 pg/ml causes an inhibition of the growth of the human cell lines is not clearly dose-dependent and less than 25% when significant. 200-1000 pg/ml melatonin cause a significant sensitization to doxorubicin.Target:Might inhibit P-glycopro tein-mediated doxorubicin efflux from the cells.
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Riferimento:Cancer Causes Control. 2001 Apr;12(3):279-87. Review.Azione della melatonina:Electric lighting contributes to 'circadian disruption' may be an important cause of 'endocrine disruption' and contribute to a high risk of breast cancer.Target:LAN
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Riferimento:Carcinogenesis. 2001 Jul;22(7):1043-8.Azione della melatonina:MF may cause uncoupling of signal transduction from melatonin receptors to adenylyl cyclase.Target:Magnetic fields/cAMP
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Titolo: Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life spanRiferimento:J Altern Complement Med. 2001 Jun;7(3):241-51.Azione della melatonina:Leukemic mice received the NK-enhancing melatonin, administered daily for 50 days. At 3 months post tumor onset, all the major hemopoietic, were recorded at normal numbers.Target:Natural-killer (NK) cells.
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Riferimento:Environ Health Perspect. 2001 May;109(5):501-7. Erratum in: Environ Health Perspect 2001 Jul;109(7):A304.Azione della melatonina:All-night exposure to magnetic fields had no effect on the blood levels of melatonin or estradiol. While nocturnal melatonin levels were suppressed in women exposed to LAN.Target:Magnetic fields (EMF) Light at night (LAN)