Melatonina
Anno: 2006
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Titolo: Circulating tumoral cells lack circadian-rhythm in hospitalized metastasic breast cancer patientsRiferimento:Clin Transl Oncol. 2006 Nov;8(11):826-9.Azione della melatonina:Increased breast tumorigenesis has been reported in melatonin-suppressed experimental models.Target:Circulating Tumor Cells (CTC) circadian- rhythm.
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Riferimento:Cancer Causes Control. 2006 May;17(4):573-6.Azione della melatonina:Melatonin may decrease risk of hormone-related cancers or even act as a potent antioxidant and thus have a protective effect against cancer development.Target:LAN
Anno: 2007
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Riferimento:Complement Ther Clin Pract. 2007 Aug;13(3):137-45.Azione della melatonina:Baseline salivary cortisol and melatonin were not significantly correlated with STAI scores and did not change significantly following reflexology.These findings will be transferred to a study involving breast cancer patients where effects display disregulation of cortisol and melatonin secretion.Target:Self-reported anxiety (STAI)
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Riferimento:Breast Cancer Res Treat. 2007 Jul;103(3):331-41.Azione della melatonina:Melatonin and estrogen in BCF predicted growth inhibition and stimulation. Biological monitoring of BCF may help identify women with GCBD at greatest risk for breast cancer development.Target:(GCBD) Gross cystic breast disease Breast cyst fluid (BCF).
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Riferimento:Am J Ther. 2007 Jan-Feb;14(1):113-5.Azione della melatonina:After 2 months the patient had a partial response, and after 5 months he achieved a complete response.Target:Treatment had very good tolerance.
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Riferimento:Crit Rev Oncog. 2007 Dec;13(4):303-28Azione della melatonina:Both human epidemiological and experimental studies on animals have documented that a potential negative consequence of chronodisruption and nocturnal melatonin inhibition is cancer initiation and growth (breast, prostate, endometrial, and colorectal).Target:LAN
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Riferimento:Cell Cycle. 2007 Jun 1;6(11):1329-31.Azione della melatonina:Here we speculate on the molecular pathways that may couple the circadian machinery to breast cancer.Target:Circadian clock
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Riferimento:Pathol Biol (Paris). 2007 Apr-May;55(3-4):201-4.Azione della melatonina:Confirmed in human the anticancer properties of MLT (20 mg/day orally), which may enhance the efficacy of the chemotherapies in colorectal cancer patients.Target:MLT may play anticancer activity.
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Riferimento:J Pineal Res. 2007 Apr;42(4):403-10.Azione della melatonina:Female mice were treated with CdCl(2) (2-3 mg/kg, i.p.), melatonin (10 microg/mL in drinking water), CdCl(2) + melatonin, or diluents. The effects of Cd are partially inhibited by melatonin.Target:Cd-induced carcinogenicity.
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Riferimento:Sleep Med. 2007 Sep;8(6):613-22.Azione della melatonina:Female shiftworkers compared to non-shiftworkers are more likely to report menstrual irregularity and longer menstrual cycles.Target:Circadian disruption.