Melatonina
Anno: 2003
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Riferimento:J Natl Cancer Inst. 2003 Jun 4;95(11):825-8.Azione della melatonina:These data suggest that working a rotating night - shift at least three nights per month for 15 or more years may increase the risk of colorectal cancer in women.Target:LAN
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Riferimento:Cancer Lett. 2003 Jan 10;189(1):49-57.Azione della melatonina:In response to exogenous melatonin, tumor incidence in the mice receiving the MT1-overexpressing MCF-7 cells was decreased by 80% compared to mice receiving vector-transfected (vt-MCF-7) cells.Target:MT1 receptor
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Riferimento:J Exp Clin Cancer Res. 2003 Jun;22(2):171-8.Azione della melatonina:May suggest the presence of self-regulation mecha-nisms between the neuroendocrine system and the cytokine network in advanced cancer patients.Target:Tumor necrosis factor alpha (TNFalpha).
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Riferimento:Anticancer Res. 2003 Mar-Apr;23(2C):1951-4.Azione della melatonina:Concomitant administration of MLT (orally at 20 mg/day) and irinotecan (CPT-11) in patients with metastatic colorectal cancer: partial response (PR) was in 5 out of 14, stable disease (SD) in 7 out of 14, disease-control achieved in patients was 12 out of 14, p < 0.05.Target:Antioxidant and immuno-modulating effects.
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Riferimento:Neuro Endocrinol Lett. 2003 Dec;24(6):440-4.Azione della melatonina:The growth of all ERalpha-positive breast cancer cell lines can be inhibited by melatonin (10(-9)M).Target:Estrogen receptors
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Riferimento:Epidemiology. 2003 Sep;14(5):514-20.Azione della melatonina:The results of this large investigation are consistent with those of most previous studies, and do not support the hypothesis that electric blanket use is associated with increased breast cancer risk.Target:EMF
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Riferimento:Breast Cancer Res Treat. 2003 Jun;79(3):313-20.Azione della melatonina:The first biological evidence for a potential link between constant light exposure and increased human breast oncogenesis involving MLT suppression and stimulation of tumor linoleic acid (LA)metabolism.Target:LAN/Linoleic Acid(LA)
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Riferimento:Crit Rev Oncol Hematol. 2003 Jun;46(3):221-34.Azione della melatonina:Pineal peptide preparation Epithalamin and synthetic tetrapeptide Epitalon (Ala-Glu-Asp-Gly) are potent inhibitors of mammary carcinogenesis in ro-dents and might be useful in the prevention of breast cancer in women at risk.Target:LAN
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Riferimento:Endocr Relat Cancer. 2003 Jun;10(2):153-9.Azione della melatonina:Melatonin (1 nM) down-regulates the expression of estrogen receptor (ERalpha) and inhibits the binding of the estradiol-ER complex to the estrogen response element (ERE) in the DNA.Target:Eralpha/ERE
Anno: 2004
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Riferimento:Cancer Lett. 2004 Dec 8;216(1):73-80.Azione della melatonina:These results support a cross-talk between membran and nuclear melatonin signalling and provide new data on the hormonal regulation of telomerase function (telomerase reverse transcriptase/TERT, telo-merase RNA/TR).Target:TERT/TR.