Melatonina
Anno: 2008
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Riferimento:J Natl Cancer Inst. 2008 Jun 18;100(12):898-905.Azione della melatonina:Statistically significant inverse association between melatonin levels, as measured in overnight morning urine, and invasive breast cancer risk in postmeno pausal women.Target:6-sulfatoxymelatonin.
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Riferimento:Carcinogenesis. 2008 Jun;29(6):1244-8.Azione della melatonina:Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors.Target:HumanTelomerase ReverseTranscriptase (hTERT)
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1418-23.Azione della melatonina:Exposure to light at night has implications for the risk of breast cancer in postmenopausal women.Target:6-sulfatoxymelatonin.
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Riferimento:Carcinogenesis. 2008 Jun;29(6):1244-8.Azione della melatonina:Sleep duration may influence breast cancer risk, possibly via its effect on melatonin levels.Target:6-sulfatoxymelatonin.
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Titolo: Physiological effects of melatonin: role of melatonin receptors and signal transduction pathwaysRiferimento:Prog Neurobiol. 2008 Jul;85(3):335-53.Azione della melatonina:Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.Target:Membrane MT1 and MT2 receptors,quinone reducta-se 2, calmodulin, calreti-culin and tubulin.
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Riferimento:J Pineal Res. 2008 Apr;44(3):307-15.Azione della melatonina:Melatonin administration (2 mg/kg BW/day) increased the BT rhythm amplitude and phase stability, reduced tumor weight and prevented intraperitoneal dissemination.Target:Body Temperature (BT)
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Riferimento:J Pineal Res. 2008 Aug;45(1):86-92.Azione della melatonina:Melatonin, at physiologic concentrations, modulates the inhibition of sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) activity.Target:Sulfatase (STS) 17beta-HSD1
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Riferimento:Mol Cell Biochem. 2008 Dec;319(1-2):175-80.Azione della melatonina:Supplementation of diet with lycopene with melatonin provided antioxidant defense with strong chemo preventive activity against DMBA-induced mammary tumors.Target:7,12-dimethylbenz(a) anthracene (DMBA)
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Riferimento:J Pineal Res. 2008 Nov;45(4):476-88.Azione della melatonina:The growth-inhibitory actions of melatonin are mediated via both G(alphai2) and G(alphaq) proteins.Target:MT1 G protein-coupled receptor.
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Riferimento:Biochem Pharmacol. 2008 Feb 1;75(3):713-24.Azione della melatonina:Indole-3-carbinol (I3C)induces a G1 cell cycle arrest of human breast cancer cells,whereas both tryptophol and melatonin failed to induce the cell cycle arrest.Target:Indole-3-carbinol (I3C)