Neoplasie della mammella
Anno: 1997
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Riferimento:Wien Klin Wochenschr. 1997 Oct 3;109(18):722-9. Review. German.Azione della melatonina:Yet unknown chemical structure are capable of inhibiting in vitro cell lines resistant to melatonin.Target:Progressive decline of pineal melatonin secretion.
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Riferimento:J Pineal Res. 1997 Sep;23(2):53-8.Azione della melatonina:Decreased pineal melatonin secretion in breast cancer patients as well as an inverse relationship with tumor-size.Target:6-sulphatoxymelatonin (aMT6s)
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Riferimento:Cancer Res. 1997 May 15;57(10):1909-14.Azione della melatonina:10 microM L-buthionine-[S,R]-sulfoximine(L-BSO) blocks the oncostatic action of 1nM melatonin, glutathione(1microM) is required for melatonin action.Target:Glutathione.
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Riferimento:J Pineal Res. 1997 May;22(4):184-202. Review.Azione della melatonina:Melatonin could indeed be considered a physiological anticancer substance.Target:Antioxidative functions, indirect immunostimulatory effects.
Anno: 1998
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Titolo: Melatonin attenuates hydrogen peroxide toxicity in MCF7 cells only at pharmacological concentrationsRiferimento:Biochem Biophys Res Commun. 1998 Sep 29;250(3):602-5.Azione della melatonina:Melatonin is an excellent oxygen radical scavenger at 10(-5) and 10(-4) M concentrations.Target:Oxygen radical scavenger.
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Titolo: Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cellsRiferimento:Cancer Res. 1998 Oct 1;58(19):4383-90.Azione della melatonina:Pretreatment of MCF-7 cells with 1 nM melatonin increased the response of tumoral cells to the antiinvasive effects.Target:Anti-invasive actions.
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Riferimento:Epidemiology. 1998 Sep;9(5):490-4.Azione della melatonina:Blind people have a lower cancer incidence, although other explanations than the higher melatonin exposure must also be considered.Target:Totally blind people.
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Riferimento:Lancet. 1998 Aug 22;352(9128):626.Azione della melatonina:No abstract available.Target:No abstract available.
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Titolo: Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factorsRiferimento:Mol Cell Endocrinol. 1998 Jun 25;141(1-2):53-64.Azione della melatonina:Melatonin and EGF transactivate the ER, making the ER refractory to activation by estradiol.Target:Estrogen receptor (ER), epidermal growth factor (EGF).
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Riferimento:Menopause. 1998 Spring;5(1):60-4. Review.Azione della melatonina:Melatonin might be implicated in menopause-associated processes such as breast cancer.Target:Melatonin replacement therapy.