Riferimento:
Cell Cycle. 2007 Jun 1;6(11):1329-31.
Autori:
Sahar S, Sassone-Corsi P.
Fonte:
Department of Pharmacology, School of Medicine, University of California at Irvine, Irvine, California 92697, USA.
Anno:
2007
Azione:
Here we speculate on the molecular pathways that may couple the circadian machinery to breast cancer.
Target:
Circadian clock
Abstract: The circadian clock controls a large array of behavioral and physiological systems of fundamental importance to most organisms.
Abstract
The circadian clock controls a large array of behavioral and physiological systems of fundamental importance to most organisms. Consequently, abnormal functioning of the clock results in severe dysfunctions and pathologies. Although epidemiological studies show a clear correlation between disruption of circadian rhythms and incidence of breast cancer, a molecular interpretation of how clock-related mechanisms may link to tumor development remains elusive. Here we speculate on the molecular pathways that may couple the circadian machinery to breast cancer.
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