Serial transplants of 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Fischer rats as model system for human breast cancer. 3. Quantitative ultrastructural studies of the pinealocytes and plasma melatonin concentrations in rats bearing an advance

Riferimento: 
Biol Signals. 1994 Nov-Dec;3(6):302-6.
Autori: 
Karasek M, Marek K, Zielinska A, Swietoslawski J, Bartsch H, Bartsch C.
Fonte: 
Biol Signals. 1994 Nov-Dec;3(6):302-6.
Anno: 
1994
Azione: 
Plasma melatonin concentrations in tumor-bearing rats killed at 3.00 h were suppressed by 35% when compared to the control animals killed at the same time.
Target: 
Plasma melatonin concentrations

Abstract

The aim of the present study was to investigate the ultrastructure of pinealocytes and plasma melatonin concentrations in Fischer rats bearing an advanced (14th) passage 7,12-dimethylbenz[a]anthracene-induced mammary tumor. Quantitative ultrastructural analysis of the cell size and relative volumes of various cell organelles as well as the number of dense-core vesicles was performed in pinealocytes of the animals killed either during the daytime (15.00 h) or at night (3.00 h) 1 month after tumor transplantation. No significant differences between control and tumor-bearing animals were observed either during the daytime or at night. However, plasma melatonin concentrations in tumor-bearing rats killed at 3.00 h were suppressed by 35% (p < 0.025) when compared to the control animals killed at the same time.

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