Riferimento:
Blood. 2011 Jan 6;117(1):242-5.
Autori:
Such E, Cervera J, Valencia A, Barragán E, Ibañez M, Luna I, Fuster O, Perez-Sirvent ML, Senent L, Sempere A, Martinez J, Martín-Aragonés G, Sanz MA
Fonte:
Blood. 2011 Jan 6;117(1):242-5.
Anno:
2011
Azione:
Coinvolgimento del recettore gamma del gene dell'acido retinoico (RARG) in una trascrizione di fusione chimerica di geni nella leucemia mieloide umana.
Target:
RARG/leucemia mielode acuta.
Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia.
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