Topical tretinoin, another failure in the pursuit of practical chemoprevention for non-melanoma skin cancer

Riferimento: 
J Invest Dermatol. 2012 Jun;132(6):1532-5.
Autori: 
Wu PA, Stern RS.
Fonte: 
J Invest Dermatol. 2012 Jun;132(6):1532-5.
Anno: 
2012
Azione: 
Questo studio non è riuscito a dimostrare un beneficio terapeutico della Tretinoina topica sul cancro della pelle non-melanoma (NMSC).
Target: 
Tretinoina/ cancro della pelle non-melanoma.

ABSTRACT

Given the high incidence of non-melanoma skin cancer (NMSC), a preventative intervention would be desirable. Except for regular sunscreen use, the quest for chemoprevention of NMSC in the general population has been unsuccessful. Weinstock et al. assessed the effects of 0.1% topical tretinoin on NMSC. Like earlier efforts at chemoprevention, this study failed to show therapeutic benefit. Future successful preventative strategies will likely rely on short-term, intermittent therapy or treatments used for other common indications.
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