Melatonina

Growth-inhibitory action of melatonin and thiazolidinedione derivative CGP 52608 on murine 16/C breast cancer cells

Neuro Endocrinol Lett. 2006 Jun;27(3):351-4.
Winczyk K, Lawnicka H, Pawlikowski M, Kunert-Radek J, Karasek M.
The effects of MLT and CGP 52 608 (the selective ligand for nuclear RZR/ROR receptors) were comparable with suppression caused by methotrexate.
CGP 52608

Circulating tumoral cells lack circadian-rhythm in hospitalized metastasic breast cancer patients

Clin Transl Oncol. 2006 Nov;8(11):826-9.
García-Sáenz JA, Martín M, Maestro M, Vidaurreta M, Veganzones S, Villalobos L, Rodríguez-Lajusticia L, Rafael S, Sanz-Casla MT, Casado A, Sastre J, Arroyo M, Díaz-Rubio E.
Increased breast tumorigenesis has been reported in melatonin-suppressed experimental models.
Circulating Tumor Cells (CTC) circadian- rhythm.

Exercise-induced stress enhances mammary tumor growth in rats: beneficial effect of the hormone melatonin

Mol Cell Biochem. 2007 Jan;294(1-2):19-24.
Sáez Mdel C, Barriga C, García JJ, Rodríguez AB, Ortega E.
Intense exercise-induced stress enhances mammary carcinogenesis through the involvement of adrenaline and prolactin, also confirmed a role of melatonin as a therapeutic aid against breast cancer in general.
"Anti-stress" role of Mlt.

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