Melatonin,at physiological concentration,suppresses estrogen receptor(ER) gene, modulates several estrogen dependent regulatory proteins and pro-oncogenes, inhibits cell proliferation, and impairs the metastatic capacity of MCF-7 human breast cancer cells.
Sleep disordered breathing (SDB)are associated with menopause. Fibromyalgia patients have increased
central nervous system levels of the nociceptive neuropeptide substance P (SP). High SP and low serotonin have significant potential to affect sleep and mood.
Baseline salivary cortisol and melatonin were not significantly correlated with STAI scores and did not change significantly following reflexology.These findings will be transferred to a study involving breast cancer patients where effects display disregulation of cortisol and melatonin secretion.
Sanchez-Mateos S, Alonso-Gonzalez C, Gonzalez A, Martinez-Campa CM, Mediavilla MD, Cos S, Sanchez-Barcelo EJ.
In ovariectomized rats,melatonin reduced food intake and partially prevented the increase of body weight and cholesterol, without changing leptin levels.
Nurses who attend night shifts should undergo strict and periodical breast cancer screening, since the risk is significantly increased in this population.
Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2509-12.
Nagata C, Matsubara T, Hara T, Fujita H, Nagao Y, Yamamoto S, Shibuya C, Kashiki Y, Shimizu H.
In premenopausal women, the urinary aMT6-s level
was significantly positively associated with percent mammographic density. No evidence that the melatonin level is inversely associated with mammographic density.