These results support a cross-talk between membran and nuclear melatonin signalling and provide new data on the hormonal regulation of telomerase function (telomerase reverse transcriptase/TERT, telo-merase RNA/TR).

Exogenous melatonin supplementation along with reduced effect of shift work is very important from the practical point of view.

Melatonin (1 nM) decreases aromatase activity and expression in MCF-7 cells.

Epidemiologic studies should consider gene and environment interactions such as circadian gene variants and shift work requirements on the job.

No abstract available.

Melatonin (10(-10) M) caused a transient inhibition of cell growth of estrogen receptor alpha-positive MCF-7-EMF cells induced synergistically by both insulin-like growth factor-1 and bisphenol A.

These antiestrogenic mechanisms suggest that melatonin may have an important role in the prevention and treatment of hormone-dependent mammary cancer.

This demonstrates that GPCRs can modulate the transcriptional activity of various steroid receptors (Eralpha, GR, RARalpha) in response to their ligand through activation of different G protein signaling pathways.

Significant positive association between vegetable intake and urinary aMT6-s levels. This association may be explained by the melatonin contained in vegetables.

We propose to realise a phase II randomised study melatonin versus placebo in metastatic breast cancer patients after two lines of treatment.