Defining chronodisruption
J Pineal Res. 2009 Apr;46(3):245-7.
Erren TC, Reiter RJ.
Melatonin being a key biological intermediary, via circadian disruption with epidemic cancers such as of the breast or prostate.
Chronodisruption (CD)
Melatonina
Long-term exposure to magnetic fields and the risks of Alzheimer's disease and breast cancer: Further biological research
Pathophysiology. 2009 Aug;16(2-3):149-56.
Davanipour Z, Sobel E.
Exposure to ELF/MF increase the risk of both Alzheimer's disease and breast cancer, increasing production of amyloid beta/decreasing production of Mlt.
Extremely low frequency (ELF), magnetic fields (Mfs).
Nighttime use of special spectacles or light bulbs that block blue light may reduce the risk of cancer
Med Hypotheses. 2009 Sep;73(3):324-5.
Alpert M, Carome E, Kubulins V, Hansler R.
Wearing amber glasses(or using blue-free light bulbs) for a few hours before bedtime maximizes melatonin production and reduces the risk of breast, ovarian and prostate cancer.
Blue wavelengths=loss of melatonin.
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Int J Epidemiol. 2009 Aug;38(4):963-70.
Stevens RG.
Nocturnal light-induced disruption of circadian rhythms, notably reduction of melatonin synthesis. Using dim red light for nighttime necessities, and not taking melatonin tablets.
LAN
Actual and potential agents and biomarkers in the treatment of cancer
Anticancer Agents Med Chem. 2009 Jun;9(5):500-16.
Carrera MP, Ramírez-Expósito MJ, Martínez-Martos JM.
We should seriously consider alternative mechanisms such as melatonin or retinoic acid,that may be beneficial to patients' well being.
Increasing survival and patients' quality of life.
Membrane-bound melatonin receptor MT1 down-regulates estrogen responsive genes in breast cancer cells
J Pineal Res. 2009 Aug;47(1):23-31.
Girgert R, Hanf V, Emons G, Gründker C.
Treatment of MCF-7 breast cancer cells with melatonin counteracted the increase induced by estradiol almost completely.
Membrane-bound receptor MT1.
Coexpression of the melatonin receptor 1 and nestin in human breast cancer specimens
J Pineal Res. 2009 May;46(4):422-32.
Rögelsperger O, Ekmekcioglu C, Jäger W, Klimpfinger M, Königsberg R, Krenbek D, Sellner F, Thalhammer T.
Expression of MT1 and coexpression of MT1/ nestin in invading tumor cells in more advanced tumors suggest an important role for GPCR in pathogenesis of breast cancer.
G-protein-coupled receptor (GPCR).
Total visual blindness is protective against breast cancer
Cancer Causes Control. 2009 Nov;20(9):1753-6.
Flynn-Evans EE, Stevens RG, Tabandeh H, Schernhammer ES, Lockley SW.
Blind women withNPL(no perception of light)appear to have a lower risk of breast cancer, compared to blind women with LP. Mechanisms influenced by melatonin or circadian synchronization.
Blindness.
Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells
Br J Cancer. 2009 Nov 3;101(9):1613-9.
Martínez-Campa C, González A, Mediavilla MD, Alonso-González C, Alvarez-García V, Sánchez-Barceló EJ, Cos S.
Melatonin(1nM)inhibits aromatase activity and expression by regulating the gene expression of specific aromatase promote region pI.4, and inhibit COX-2 and COX-1 mRNA expression.
COX-2/COX-1 mRNA expression.
[MT1 melatonin receptors and their role in the oncostatic action of melatonin]
Postepy Hig Med Dosw (Online). 2009 Sep 15;63:425-34.
[Article in Polish] Danielczyk K, Dziegiel P.
MT1 melatonin receptors benefits the efficacy of melatonin treatment.
MT1 (Mel1a) and MT2 (Mel1b) receptors.
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