Melatonina

Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer

J Mammary Gland Biol Neoplasia. 2011 Sep;16(3):235-45.
Hill SM, Blask DE, Xiang S, Yuan L, Mao L, Dauchy RT, Dauchy EM, Frasch T, Duplesis T.
Light-at-night (LAN) induced circadian disruption of the nocturnal melatonin signal activates human breast cancer growth.
MT(1)melatonin receptors Estrogen receptor-positive (Erα+), G(αi2) signaling.

A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis

Eur J Cancer Prev. 2012 Mar;21(2):163-70.
Kisková T, Ekmekcioglu C, Garajová M, Orendáš P, Bojková B, Bobrov N, Jäger W, Kassayová M, Thalhammer T.
Resveratrol in combination with melatonin has some protective effects on N-methyl-N-nitrosourea (NMU)-induced rodent breast cancer.
Chemoprevention with resveratrol and mlt.

Melatonin pathway genes and breast cancer risk among Chinese women

Breast Cancer Res Treat. 2012 Apr;132(2):693-9.
Deming SL, Lu W, Beeghly-Fadiel A, Zheng Y, Cai Q, Long J, Shu XO, Gao YT, Zheng W.
Genetic variation in the MTNR1a and 1b genes may contribute to breast cancer, no breast cancer associations were found for variants in the AANAT gene.
Mlt receptors 1a and 1b (MTNR1a and MTNR1b), arylalkylamine N-acetyl-transferase (AANAT).

Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine production

J Pineal Res. 2012 Apr;52(3):282-90.
Alvarez-García V, González A, Alonso-González C, Martínez-Campa C, Cos S.
One millimolar melatonin induced a reduction in TNF-α, IL-6, and IL-11 mRNA expression in MCF-7 and 3T3-L1 cells.
Aromatase enzyme,tumor necrosis factor (TNF)-α, interleukin (IL)-11 and interleukin (IL)-6.

The effect of MELatOnin on Depression, anxietY, cognitive function and sleep disturbances in patients with breast cancer. The MELODY trial: protocol for a randomised, placebo-controlled, double-blinded trial

BMJ Open. 2012 Jan 11;2(1).
Hansen MV, Madsen MT, Hageman I, Rasmussen LS, Bokmand S, Rosenberg J, Gögenur I.
The effect of melatonin in a breast cancer population with the above-mentioned indications has not yet been studied.
Clock-gene, PER3.

Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

J Pineal Res. 2012 Aug;53(1):77-90.
Wang J, Xiao X, Zhang Y, Shi D, Chen W, Fu L, Liu L, Xie F, Kang T, Huang W, Deng W.
Inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-κB and PI3K/Akt/signaling and activating the Apaf-1/ caspase-dependent apoptotic pathway.
Mlt 10(-3)M

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