Melatonina

Work at night and breast cancer - report on evidence-based options for preventive actions

Scand J Work Environ Health. 2012 Jul 1;38(4):380-90.
Bonde JP, Hansen J, Kolstad HA, Mikkelsen S, Olsen JH, Blask DE, Härmä M, Kjuus H, de Koning HJ, Olsen J, Møller M, Schernhammer ES, Stevens RG, Akerstedt T.
Elevations in risk of breast cancer after about 20 years working night shift. Accelerated tumor growth by suppression of melatonin secretion.
Shift work carcinogenic to humans (group 2A).

Breast Cancer Therapy Based on Melatonin

Recent Pat Endocr Metab Immune Drug Discov. 2012 May;6(2):108-16. Review.
Sanchez-Barcelo EJ, Mediavilla MD, Alonso-Gonzalez C, Rueda N.
Based on its Selective Estrogen Receptor Modulator [SERM) and Selective Estrogen Enzyme Modulator (SEEM) properties. Its nocturnal suppression by light-at-night (LAN) has been considered a risk-factor for breast cancer.
Inhibiting activity of P450 aromatase.

Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats

Cancer Res. 2005 Dec 1;65(23):11174-84.
Blask DE,Brainard GC,Dauchy RT,Hanifin JP,Davidson LK,Krause JA,Sauer LA,Rivera-Bermudez MA,Dubocovich ML,Jasser SA,Lynch DT,Rollag MD,Zalatan F.
Tumor growth response to exposure to light during darkness is intensity dependent and that the human nocturnal, circadian melatonin signal not only inhibits human breast cancer growth but that this effect is extinguished by short-term ocular exposure to bright white light at night.
White fluorescent light

The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model

Int J Exp Pathol. 2005 Dec;86(6):383-96.
el-Aziz MA, Hassan HA, Mohamed MH, Meki AR, Abdel-Ghaffar SK, Hussein MR.
The administration of Mel, RA and NS reduced the arcinogenic effects of DMBA (dimethylbenzanthra-ne), suggesting a protective role.
Nigella Sativa Melatonin, Retinoic Acid,

Protective effect of melatonin on human peripheral blood hematopoeitic stem cells against doxorubicin cytotoxicity

Anticancer Res. 2005 Nov-Dec;25(6B):4245-8.
Greish K, Sanada I, Saad Ael-D, Hasanin E, Kawasuji M, Kawano F, Maeda H.
Importance of time sequence for melatonin administration (during or 1 hour after) to exert its protective effect to doxorubicin treatment, independent from its antioxidant function.
Antioxidant function.

Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells

Breast Cancer Res Treat. 2005 Dec;94(3):249-54.
Martínez-Campa C, González A, Mediavilla MD, Alonso-González C, Sánchez-Barceló EJ, Cos S.
Treatment with melatonin (1 nM) followed by aminoglutethimide is the most effective way of reducing the aromatase activity in the MCF-7 cell line.
Aromatase mRNA.

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