Melatonina

Seasonal influence on 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats under controlled laboratory conditions

Pharmacol Toxicol. 1997 Dec;81(6):265-70.
Löscher W, Mevissen M, Häussler B.
Seasonal variation in the development and growth of DMBA-induced breast cancer as the seasonal variation in pineal melatonin production.
Circannual rhythms.

Melatonin has no effect on the growth, morphology or cell cycle of human breast cancer (MCF-7), cervical cancer (HeLa), osteosarcoma (MG-63) or lymphoblastoid (TK6) cells

Cancer Lett. 1998 Jan 9;122(1-2):17-23.
Panzer A, Lottering ML, Bianchi P, Glencross DK, Stark JH, Seegers JC.
The direct antiproliferative effect of melatonin thus seems to be confined to a melatonin-responsive subclone of MCF-7 cells and not applicable to the majority of cancer cells.
MCF-7 human breast cancer cells.

Melatonin enhances tamoxifen's ability to prevent the reduction in microsomal membrane fluidity induced by lipid peroxidation

J Membr Biol. 1998 Mar 1;162(1):59-65.
García JJ, Reiter RJ, Ortiz GG, Oh CS, Tang L, Yu BP, Escames G.
Synergistic effects of tamoxifen (50-200 microM) and melatonin (1 mM) in stabilizing biological membranes may be important in protecting membranes from free radical damage.
Tamoxifene/Melatonin.

A sequential treatment regimen with melatonin and alA sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cellsl-trans retinoic acid induces apoptosis in MCF-7 tumour cells

Br J Cancer. 1998 Jun;77(12):2129-37.
Eck KM, Yuan L, Duffy L, Ram PT, Ayettey S, Chen I, Cohn CS, Reed JC, Hill SM.
Melatonin (10(-9) M)and atRA (10(-9) M) should be considered for preclinical and clinical evaluation against ER-positive human breast cancer.
Oestrogen receptor (ER), all-trans retinoic acid (atRA).

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